Funding: the study was supported by the RSF grant 25-75-30005 “Regulation of Body’s Cell Renewal Processes, the Fundamentals for Long-term Maintenance of Functional Activity of Organs and Tissues, Human Health and Active Longevity”.

Author contribution: Zinoveva AA, Bakhchinian E — experiments on MSC differentiation, processing of the results; Kamenkov SS — MSC isolation and culturing, statistical data processing, manuscript writing; Shcherbakova LN — clinical phase management, biomaterial acquisition, interpretation of the results, manuscript editing; Bugerenko AE, Ogay DS — clinical phase management, biomaterial acquisition; Voloshin NS — adipogenic differentiation quantification; Chechekhina ES — study concept and design, MSC isolation and culturing, interpretation of the results, manuscript writing; Kulebyakin KYu — study concept and design, interpretation of the results, manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Lomonosov Moscow State University (IRB00010587, protocol No. 4 dated 4 June 2018, protocol No. 9 dated 29 October 2018) was conducted in accordance with the principles of the Declaration of Helsinki. All the patients provided informed consent before biomaterial collection.