Despite the successful practice of using the Russian-made original peptide complex (OPC), the complex pharmacodynamics is poorly understood. The study aimed to assess the effect of taking OPC on the prostate tissue oxygen consumption rate (OCR) in white outbred rats. The experiments involved 65 adult male white outbred rats (age 6 months, body weight 410.8 ± 2.7 g). The rats were kept under standard vivarium condition, each in a separate cage; the diet and drinking regime were standard. The difference in animal housing was that animals of the experimental group (n = 49) received OPC throughout 20 days before the day of the experiment: every day 0.35 mg (0.85 mg/kg) of the drug were dissolved in 20 mL of the drinking water the animals drank from the trough. The drug was not administered to the control group (n = 16). A prostatectomy was performed. The prostate tissue OCR was measured using the DKTP-03 optical dissolved oxygen sensor with a thermoelectric converter. The О₂ concentration readings (ConО₂) in mg/L were recorded every minute throughout 60 min. Significant intergroup differences in ConО₂ values in the end of the experiment were found (р < 0.05). It has been shown that OPC increases the prostate tissue OCR in white outbred rats.