Acknowledgements: The authors express their sincere gratitude to S. Gramatyuk and M. Noebauer (UAB Global) for methodological support and significant contribution to the design, planning, and conceptualization of this experimental research.

Author contribution: Bondorenko DV, Ivanov AS — study design, experimental part of the work; Tananakina TP — study design, experimental part of the work, scientific support; Kashchenko SA — scientific text editing, scientific support, experiment preparation; Pogorelova IA — text editing, experiment preparation, animal care consultations, drug dose calculations; Alexandrov IA — animal care, experimental part of the work.

Compliance with ethical standards: the study was approved by the Ethics Committee of St. Luka LSMU, Ministry of Health of the Russian Federation (Minutes No. 1 of January 27, 2026), conducted in accordance with the Recommendations of the Board of the Eurasian Economic Commission of November 14, 2023 No. 33 "Guidelines for working with laboratory (experimental) animals during preclinical (non-clinical) studies," in compliance with the principles of the European Convention for the Protection of Vertebrates used for Experimental and Other Scientific Purposes, as well as in accordance with the Directive of the