ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Evaluation of resorbable ZN-MG alloy biocompatibility in vitro and in vivo
About authors
1 Ural State Medical University, Yekaterinburg, Russia
2 Mikheev Institute of Metal Physics, Yekaterinburg, Russia
Correspondence should be addressed: Ivan I. Gordienko
Repina, 3, Yekaterinburg, 620028, Russia; ivan‑ur.liam@okneidrog
About paper
Author contribution: Gordienko II — study conception, overall supervision of research stages, performing experimental surgeries, data interpretation, manuscript preparation; Kornilov DO — study conception, performing in vitro experiment, data interpretation, manuscript preparation; Chernyii SP — performing experimental surgeries and instrumental studies, data interpretation; Simarzina VM — performing in vitro experiment, visualization, manuscript preparation; Raspotsienko DY — synthesis of experimental metallic materials, performing structural studies, analysis of experimental results; Slukina AE — performing experimental surgeries, literature analysis, data interpretation, draft manuscript preparation; Ivasenko MI — performing experimental surgeries and instrumental studies, data interpretation; Vinokurov DE — synthesis of experimental metallic materials, thermal and deformation treatment of materials, sample preparation, performing structural studies; Zornikov DL — overall supervision of research stages, data analysis, data interpretation.
Compliance with ethical standards: The study was approved by the Local Ethics Committee of the Ural State Medical University, Ministry of Health of the Russian Federation, Yekaterinburg (Protocol No. 4 dated April 19, 2024). Informed consent is not applicable because laboratory animals were used.
Received: 2026-05-07
Accepted: 2026-05-24
Published online: 2026-06-04
|
Fig. 1. Group A — samples with 0.5 wt.% Mg, all working concentrations. Group B — samples with 1 wt.% Mg, all working concentrations
Fig. 2. Stages of surgical intervention. Implant insertion into the created bone defect. A. Preparation of a trephine hole in the proximal metaphysis of the tibia of experimental animals. B. Implantation process of a Zn-based alloy pin into the created trephine hole. C. Implanted pin tightly placed in the prepared trephine hole; final view
Fig. 3. Heat map of SCP‑1 cell viability after exposure to bioresorbable Zn–Mg alloy powders. Color scale: cold colors — low viability, warm colors — high viability
Fig. 4. Computed tomography results 3 months after surgery. The implant is visualized in the metaphyseal region of the tibia. A. Sagittal section including the diaphysis. B. Sagittal section including the epiphysis
Table 1. Hematological parameters on postoperative day 7
Note: * — Reference values for rabbits [21]; H — increasing the parameter.
Table 2. Cortical (CBD) and trabecular (TBD) bone density in the peri‑implant zone at 3 months
