ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
CLINICAL CASE
Behavioral and neurophysiological effects of the early start Denver model in a child with autism spectrum disorder
About authors
1 Vernadsky Crimean Federal University, Simferopol, Russia
2 Institute for biochemical technology, ecology and pharmacy, Vernadsky Crimean Federal University, Simferopol, Russia
3 Balaban Crimean republican clinical psychiatric hospital No. 1, Simferopol, Russia
Correspondence should be addressed: Vladimir B. Pavlenko
pr. Vernadskogo, 4, Simferopol, 295007, Russia; moc.liamg@55vapv
About paper
Funding: the work was supported by the Russian Science Foundation grant No. 25-78-10035, https://rscf.ru/en/project/25-78-10035/.
Author contribution: Pavlenko VB, Mikhailova AA — study planning, data analysis and interpretation, manuscript drafting; Berezutskaya VP, Shurygina DA — data collection and analysis, manuscript drafting.
Compliance with ethical standards: the study was approved by the Ethics Committee of the V.I. Vernadsky Crimean Federal University (Minutes No. 8 of November 27, 2025). The parents provided informed consent for their child’s participation in the study.
Received: 2026-08-03
Accepted: 2026-09-07
Published online: 2026-09-17
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Fig. EEG spectra of a child with ASD during sustained visual attention (black line) and observation of another person's actions (red line), before (A) and after (B) ESDM intervention
Table. Indicators of autism symptom severity, speech development, and helping behavior (HB) before and after ESDM intervention
