Author contribution: Ivanov AS — study planning and design, literature review, experimental procedure; Tananakina TP — study planning and design, experimental procedure, research support, manuscript writing; Kashchenko SA — scientific editing, advice on the experimental procedure, manuscript writing; Pogorelova IA — calculation of results, drug dose selection and titration, advice on animal handling; Alexandrov IA — experimental animal handling, drug administration, blood sampling for analysis, contribution to withdrawal of animals from the experiment.

Compliance with ethical standards: the study approved by the Ethics Committee of the St. Luke Lugansk State Medical University (protocol No. 2 dated September 23, 2025) was fully compliant with the Eurasian Economic Commission (EEC) Board "Guidelines for the Use of Laboratory (Experimental) Animals in Preclinical (NonClinical) Studies" dated November 14, 2023, No. 33, principles of the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes, s well as the Directive of the European Parliament and of the Council of the European Union on the Protection of Animals Used for Scientific Purposes.