Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

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Makarov OV, Kozlov PV, Kuznetsov PA, Kopylova YuV, Vinokurova IN, Dzhokhadze LS, Osmanova AP

Vascular growth factors play an important role in the formation and functioning of the fetoplacental complex. The paper analyzed angiogenic status in patients with placental insufficiency with intrauterine growth restriction and preeclampsia. In all pregnant women there was investigated serum level of PIGF, sFlt-1 and sEng at 28–34 weeks of gestation by the method of enzyme-linked immunosorbent assay. Preeclampsia and intrauterine growth restriction are characterized by a decrease in pro-angiogenic growth factors on the background of increasing concentrations of anti-angiogenic agents.

Received: 2014-10-07

Published online: 2017-01-05

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VIEWS 3245

Kozlov PV, Bogaeva II, Ivannikov NYu, Kuznetsov PA, Dzhokhadze LS

Until now strategy of management of incomplete pregnancy with registered absent end diastolic flow (AEDF) in the umbilical artery in the preterm has not been worked out. There were analyzed 29 cases of singleton pregnancy, when AEDF in the umbilical artery was registered at 25–37 weeks of gestation. It was established that in preterm pregnancy and registration of AEDF in the umbilical artery prolongation of pregnancy in order to prevent the development of respiratory distress syndrome of the fetus is possible if cardiomonitoring observation reveals normal heart rate variability, reactive non-stress test and/or normal respiratory movements and normal volume of amniotic fluid. After 34 weeks of gestation with registration of AEDF in the umbilical artery, pregnancy prolongation is inappropriate.

Received: 2014-10-07

Published online: 2017-01-05

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VIEWS 3197

Kuznetsov PA, Kozlov PV, Dzhokhadze LS, Konstantinova KI

Non-immune fetal hydrops is a heterogeneous disorder, which is the final stage of the development of different antenatal diseases of the fetus. Contrary to popular belief, the infection is not the main cause of this disease. This article describes the unique case of non-immune hydrops of one fetus from the twins.

Received: 2014-10-07

Published online: 2017-01-05

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VIEWS 2925

Miroshnichenko IV, Stolpnikova VN, Levashova TV, Sorokina EA, Toporova SG

The aim of the study was to determine the markers and the stages of the immunosenescence. The data of flowing polychrome cytometry of 155 patients at the age of 80–89 years (group 1) and 276 patients at the age of 90–104 years (group 2) were analyzed. Immunograms were picked with homogeneous quantitative changes helper CD4+, cytotoxic CD8+ and activated CD3+HLA-DR+ T-cells. The average absolute values of indices with the analogous type of deviations from the standard did not depend on the age. However in the 2nd group persons with immunodeficiency were identified more often (80 ± 5 %) and less with activation of immunity (20 ± 5 %), than in the 1st group (33.5 ± 7.5 % and 66.5 ± 7.5 %, accordingly). It was assumed that the change of types of deviations from the standard reflects the sequential stages of natural immunosenescence, associated with quantitative CD4+ and/or CD8+ deficiency. Possibly the immune inflammation stimulates the accelerated aging against this background.

Received: 2014-05-30

Published online: 2017-01-05

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VIEWS 3336

Arshanskaya EG, Semochkin SV, Sotnikov VM, Ivanova VL

This article presents the analysis of long-term results of therapy of adolescents (n = 48; median age — 16.6 years; minimum and maximum age — 15.0 and 18.1) and young adults (n = 49; median age — 21.0 years; minimum and maximum age — 18.5 and 33.6) with primary Hodgkin's lymphoma (HL). During 1997–2008 all the patients were treated according to the pediatric protocol DAL-HD-90. Twelve-year event-free survival was 73.4 ± 4.8 % and overall survival — 81.5 ± 4.7 % for all patients. Twelve-year event-free survival for adolescents at the early stages of HL was documented at the level of 83.3 ± 15.2 %, at the intermediate stages — 80.9 ± 10.0 % and at the advanced stages — 72.2 ± 9.8 %. Long-term treatment results of young adults with intermediate and advanced stages of HL were inferior to those of adolescents. The frequency of secondary tumors in all patients was in 2.1 % of cases.

Received: 2014-06-24

Published online: 2017-01-05

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VIEWS 3257

Beloglazov VA, Popenko YoU

The aim of our investigation was to determine the state of anti-endotoxin (AET) immunity in patients with moderate and severe persistent bronchial asthma. 109 patients were examined receiving outpatient treatment of the basic disease. All patients were divided into two groups: group 1 — patients with moderate bronchial asthma — 68 subjects (62,4%) with average score of 3.00 ±0.14 according to ACQ, FEV<sub>1</sub> — 67.01 ± 2.10 %; group 2 — patients with severe bronchial asthma — 41 subjects (37,6 %) with average score of 4.06 ± 0.12 according to ACQ, FEV<sub>1</sub> — 34.45 ± 1.05 %. It was proved that in both clinical groups the levels of total secretory IgA and secretory AET-lgA in induced sputum were higher than those of healthy donors. It was observed the increase of the level of AET-IgM in blood serum in both clinical groups in comparison with donors, as for the level of serum AET-IgG patients of the studied groups were treated as normal responders. It was registered the increased level of AET-lgA in blood serum in group 1, in group 2 this indicator was getting closer to that of the donors. The increased level of C-reactive protein was determined in both groups. It is assumed that the imbalance of anti-endotoxin immunity influences the severity and the course of bronchial asthma according to the phenomenon of endotoxin aggression.

Received: 2014-06-06

Published online: 2017-01-05

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VIEWS 3207

Agapov MA, Gorskiy VA, Petrov VA, Polivoda MD, Kravchenko AYu, Battaev AI

The study of pathogenesis of acute pancreatitis and exploration of new treatment strategies are among the main scientific directions of urgent surgery. In connection with this, experimental models of acute pancreatitis are still an important research tool. In this review the invasive and noninvasive models of acute pancreatitis are presented. There are discussed disadvantages and positive features of each model.

Received: 2016-04-04

Published online: 2017-01-05

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VIEWS 3198

Sviridov SV, Malyshev AA

The purpose of the study was to evaluate the efficiency of multimodal analgesia in patients after extensive laparoscopic surgery on the organs of the gastrointestinal tract (GIT). The study involved 127 surgical patients aged 65 ± 13 years, operated routinely using the laparoscopic technique (group 1) or laparotomy (group 2). According to the method of anesthesia in the first group there were identified 2 subgroups: in the 1A subgroup there was used a combination of nonnarcotic anti-inflammatory drugs and epidural analgesia (EA) and in the 1 В subgroup epidural analgesia was not applied. Anesthesia in patients of group 2 was performed according to the method of the 1A subgroup. In the postoperative period, on the 2nd, 6th and 11th days there was made a dynamic estimation of parameters of central hemodynamics (CHD) using noninvasive rheographic techniques; as well as an assessment of pain and physical activity. There was identified early recovery of physical activity in the 1B subgroup, despite more intense pain syndrome in comparison with the 1A and the 2nd groups. The estimation of parameters of CHD had the highest decrease of myocardial contractility in the 1 В subgroup followed by reduction of the initial values by the 11th day. According to the results of the study there was made a conclusion that the epidural analgesia should be considered as a mandatory component of intra- and postoperative anesthesia when performing extensive laparoscopic surgery on the organs of the gastrointestinal tract.

Received: 2014-09-02

Published online: 2017-01-05

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VIEWS 3068