Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

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Uchaykin VF, Shamsheva OV

The clinical picture of an infectious disease, the character of its course, the outcomes depend on the mode of entry. When infection occurs naturally there happens an adequate immune response, the disease manifests typical symptoms, proceeds cyclically and ends with the recovery with formation of a full-fledged sterile immunity. In the case of hematogenous infection these is no full mode of entry and there may develop fulminant forms of the disease or a chronic course with the involvement of visceral organs in the process. Sterilizing immunity is not formed in this case. Complete sanogenesis requires the presence of the pathogen or its mediators in the primary site of infection. HIV, hepatitis C and B, tetanus, rabies should be treated as infectious diseases occurring due to the mechanisms of tropism's change. It provides the emergence of new tropism substrates with subsequent involvement in the process of visceral organs. The challenge for the future is to search for specific mediators of the immune response, triggering and controlling all stages of a germ and macroorganism interaction.

Received: 2013-09-04

Published online: 2017-01-05

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VIEWS 4168

Chulkova SV, Lyzhenkova MA, Bocharova OA, Egorova AV, Lepkova NV

The article is a review dedicated to one of the most actual aspects of oncology — the use of phytoadaptogens in the therapy of neoplastic diseases. It discloses modern status of the problem as well as underlines most disputable sides of it. The article produces the main properties of phitoadaptogen (antioxidant, antimutagen, antiinflammatory). There is also discussed the ability of the phytoadaptogens to regulate intercellular adhesion and to induce the formation of endogenous interferon.

Received: 2013-06-14

Published online: 2017-01-05

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VIEWS 4045

Egorova AV, Chulkova SV, Lepkova NV, Peterson SB, Sholokhov VN, Narimanov MN

The purpose of this study is to assess possibilities of ultrasonic tomography (UST) in the diagnosis of delineated liquid clusters in the patients operated on for stomach cancer. In the study there were analyzed data of 1500 patients operated on for stomach cancer in N.N.BIokhin Russian Cancer Research Center of RAMS for the period from 1998 to 2006. In 221 patients (14.7 %) there were suspected post-operative complications in clinical and laboratory data. 54 patients (3.6 %) were diagnosed with post-operative complications. The latter constituted the main group in our study. Fluid accumulation in the abdominal cavity is formed with equal frequency in all variants of surgical intervention in patients, operated on for stomach cancer. In the diagnosis of abscesses and hematomas UST is characterized by high sensitivity, however, specificity and accuracy of this method does not reach the desired values. The effectiveness of UST and X-ray computed tomography are comparable, X-ray diagnostics has low indicators of sensitivity.

Received: 2013-06-14

Published online: 2017-01-05

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VIEWS 4012

Darenkov SP, Krivoborodov GG, Kotov SV, Dzitiev VK, Proskokov AA, Pinchuk IS

Radical cystectomy still remains an operative treatment with a significant number of early postoperative complications. This literature review covers the most common postoperative complications of radical cystectomy with intestinal plasticity, such as impaired microcirculation, intestinal paresis, metabolic changes. It is shown the need for further study of the etiology, pathogenesis and the course of postoperative complications. This will develop the optimal strategy for the management of patients after radical cystectomy.

Received: 2013-09-03

Published online: 2017-01-05

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VIEWS 4158

Zenkov SS, Nemenova AA, Berestennikov KA, Prityko AA

This article concerns matters of epidemiology, diagnostics and treatment of coral nephrolithiasis. It also touches upon modern classification and the problems of the course of the disease in patients with a single or the only one functioning kidney. The article depicts detailed description of the basic methods of operational treatment as well as the place of percutaneous X-ray and endoscopic surgeries in the treatment of patients with coral nephrolithiasis with a single kidney. Additionally there are reflected complications arising when performing these operations.

Received: 2013-08-28

Published online: 2017-01-05

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VIEWS 4096

Nikolskaya IA, Kopetskiy IS, Volkov AG, Dikopova NJ, Nosov VV

Currently actively conducted research on the application of various biomaterials and the development of special methods of influence on the tissues allow in complex in the treatment process to influence on the metabolic and regenerative processes in the pulp tissues. Improving the quality of the treatment of reversible pulpitis by application of ozone therapy in combination with the method of direct pulp capping with materials based on calcium hydroxide is aimed at preserving the viability and stimulation of the regenerative function of tooth pulp.

Received: 2013-09-18

Published online: 2017-01-05

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VIEWS 4231

Kruglikov GG, Suslov VB, Likhacheva LM, Stranzha NB, Oettinger AP

In the conditions of inflammation and hypoxia the destructive processes are noted in all cells of the air-blood barrier, basement membranes and in the interstitium. The basis of pathological processes in cells with short and long lives cycles are violations of the energy metabolism in mitochondria. Structural and functional characteristics of long-living cells promote the greater resistance to oxygen deficiency. The increase in the number of poikilocytes among red blood cells in the alveolar capillaries may serve as an indicator of local hypoxia.

Received: 2013-07-02

Published online: 2017-01-05

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VIEWS 4306

Pogodin PV, Lagunin AA, Ivanov SM, Konova VI, Filimonov DA, Poroykov VV

The purpose of the study is development of a specialized version of the computer system PASS — PASS Targets for computer-aided prediction of the spectra of interactions between chemical compounds and protein-targets based on ChEMBLdb database (14 version). Data on the interaction between 348 137 different compounds and protein-targets were extracted from ChEMBLdb and were used for PASS training. The average prediction accuracy calculated by leave-one-out cross-validation procedure is 98.1 %. The developed copputer system PASS Targets and be used to predict interaction with 3257 protein-targets representing eight major classes of protein-targets of 215 species.

Received: 2013-07-01

Published online: 2017-01-05

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VIEWS 4008