2015 / 04

Next Paper

ORIGINAL RESEARCH

The impact of IL10 gene polymorphism on manifestations and severity of pdoriasis

Galimova ES1,2, Khusnutdinova EK
About authors

1 Institute of Biochemistry and Genetis, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia

2 Univerity of Tartu, Tartu, Estonia

Correspondence should be addressed: Elvira S. Galimova
71, Lenina av., Ufa, Russia, 450054; ur.xednay@4-ayle

About paper

Funding: the study was supported by grants from the Russian Foundation for Basic Research No. 13-04-01489 A and No. 14-04-97026.

Received: 2015-09-13 Accepted: 2015-10-22 Published online: 2017-01-05
|
  1. Krueger G, Bowcock A. Psoriasis pathophysiology: current concepts of pathogenesis. Ann Rheum Dis. 2005; 64: 30–6.
  2. Sa SM, Valdez PA, Wu J, Jung K, Zhong F, Hall L, et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol. 2007; 178: 2229–40.
  3. Kingo K, Koks S, Silm H, Vasar E. IL-10 promoter polymorphisms influence disease severity and course in psoriasis. Genes Immun. 2003; 4 (6): 455–7.
  4. Kingo K, Koks S, Nikopensius T, Silm H, Vasar E. Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis. Genes Immun. 2004; 5 (2): 117–21.
  5. Koks S, Kingo K, Ratsep R, Karelson M, Silm H, Vasar E. Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis. Genes Immun. 2004; 5: 662–7.
  6. Koks S, Kingo K, Vabrit K, Ratsep R, Karelson M, Silm H, et al. Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis. Genes Immun. 2005; 6 (5): 407–15.
  7. Galimova E, Akhmetova V, Latipov B, Kingo K, Ratsep R, Traks T, et al. Analysis of genetic variants of class II cytokine and their receptor genes in psoriasis patients of two ethnic groups from the Volga-Ural region of Russia. J Dermatol Sci. 2012; 68 (1): 9–18.
  8. Mathew CC. The isolation of high molecular weight eucariotic DNA. Methods Mol Biol. 1984; 2: 31–4.
  9. Guo SW, Thompson EA. Performing the exact test of Hardy-Weinberg proportions for multiple alleles. Biometrics. 1992; 48: 361–72.
  10. Yoo KH, Kim SK, Chung JH, Chang SG. Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 2011; 26 (5): 659–64.
  11. Ladhani SN, Davila S, Hibberd ML, Heath PT, Ramsay ME, Slack MP, etal. Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children. Clin Infect Dis. 2010; 51 (7): 761–7.
  12. Aggarwal S, Ali S, Chopra R, Srivastava A, Kalaiarasan P, Malhotra D, et al. Genetic variations and interactions in anti-inflammatory cytokine pathway genes in the outcome of leprosy: a study conducted on a MassARRAY platform. J Infect Dis. 2011; 204 (8): 126–73.
  13. Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, et al. Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet’s disease susceptibility loci. Nat Genet. 2010;42(8):703–6.
  14. Fife MS, Gutierrez A, Ogilvie EM, Stock CJ, Samuel JM, Thomson W, et al. Novel IL10 gene family associations with systemic juvenile idiopathic arthritis. Arthritis Res Ther. 2006; 8 (5): r148.
  15. Langsenlehner U, Krippl P, Renner W, Yazdani-Biuki B, Eder T, Koppel H, et al. Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk. Breast Cancer Res Treat. 2005; 90 (2): 113–5.
  16. Macarthur M, Sharp L, Hold GL, Little J, El-Omar EM. The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland. Cancer Epidemiol Biomarkers Prev. 2005; 14 (7): 1613–8.
  17. Xie G, Myint PK, Zaman MJ, Li Y, Zhao L, Shi P, et al. Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population. PloS One. 2013; 8 (9): e74126.
  18. Malarstig A, Eriksson P, Hamsten A, Lindahl B, Wallentin L, Siegbahn A. Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome. Heart. 2008; 94 (6): 724–9.