ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Distribution of intravenously injected small interfering RNAs in organs and tissues
About authors
1 Laboratory of Molecular Genetics of Complexly Inherited Diseases,Research Centre of Medical Genetics, Moscow, Russia
2 Preobrazhensky Department of Chemistry and Technology of Bioactive Compounds,Institute of Fine Chemical Technologies, Moscow, Russia
Correspondence should be addressed: Andrei Alimov
ul. Moskvorechie, d. 1, Moscow, Russia, 115478; ur.xednay@0102vomila.ierdna
About paper
Acknowledgements: authors thank Olga Konyaeva and Natalia Kulbachevskaya of Blokhin Russian Cancer Research Center for providing consultations and technical assistance with the animals.
Contribution of the authors to this work: Kuzevanova AYu — analysis of literature, data collection, analysis, and interpretation; Luneva AS — preparation of liposomes; Maslov MA — research planning, preparation of liposomes; Karpukhin AV — analysis of literature, research planning, data interpretation, drafting of a manuscript; Alimov AA — analysis of literature, research planning, data collection, analysis and interpretation, drafting of a manuscript. All authors participated in editing of the manuscript.
Received: 2017-06-20
Accepted: 2017-06-24
Published online: 2017-07-19
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Accumulation of siRNA in the organs of mice after the intravenous injection. Differences between the experimental and control groups were significant for liver, spleen, kidney and lung tissues (p < 0.05). (A) Administered dose of 2.5 mg/kg. (B) Administered dose of 7.5 mg/kg
