ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Significance of miR-146a quantification in human blood plasma for the diagnosis of colorectal cancer
About authors
1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia
2 City Hospital No. 40, Saint Petersburg, Russia
3 City Clinical Hospital No. 1, Novosibirsk, Russia
4 Novosibirsk State Medical University, Novosibirsk, Russia
5 Novosibirsk State University, Novosibirsk, Russia
Correspondence should be addressed: Maxim L. Filipenko
Prospekt Ak. Lavrientieva, d. 8, Novosibirsk, Russia, 630090; ur.csn.hcobin@xam
About paper
Funding: this works was supported by the Federal Targeted Program for Research and Development in Priority Areas of Advancement of the Russian Scientific and Technological Complex for 2014–2020 (Grant No. 14.604.21.0101, ID RFMEFI60414X0101).
All authors' contribution to this work is equal: selection and analysis of literature, research planning, data collection, analysis, and interpretation, drafting of a manuscript, editing.
Received: 2017-08-25
Accepted: 2017-08-30
Published online: 2017-10-30
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Fig. 1. Distribution of normalized miR-146a concentrations expressed in arbitrary units in 10 plasma pools obtained from patients with colorectal cancer (Т) and controls (C)
Fig. 2. Distribution of normalized miR-146a concentrations expressed in arbitrary
units in patients with colorectal cancer (Т) and controls (C)
Fig. 3. The ROC-curve (shown in blue) constructed from the distribution of measured miR-146a concentrations expressed in arbitrary units for patients with and without colorectal cancer. Confidence intervals are represented by grey curves
Table 3. Nucleotide sequences of oligonucleotide primers and hydrolizable fluorescently labeled probes used in the study
Table 4. Analysis of miR-146a levels circulating in the blood plasma of patients with colorectal cancer (T) and controls (C)
