ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Levels of cell-free DNA and DNAse I activity in complicated and normal pregnancies
About authors
1 Department of Obstetrics and Gynecology, Faculty of Pediatrics,Pirogov Russian National Research Medical University, Moscow
2 Laboratory of Molecular Biology, Research Centre for Medical Genetics, Moscow
Correspondence should be addressed: Kristina G. Avetisova
Sevastopol avenue, 24a, Moscow, 117209; ur.xednay@6102avositeva.c
Received: 2018-03-15
Accepted: 2018-06-27
Published online: 2018-09-15
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Table 1. Characteristics of patients with IUGR of the fetus
Note: results are presented as median values (the maximum value ÷ the minimum value); р1 is the р value indicating the difference from the group of pregnant patients with grade I IUGR; р2 is the р value indicating the difference from the group of pregnant patients with grade II IUGR.
Table 2. Concentrations of plasma cfDNA and the activity of DNase I in healthy nonpregnant women and women with normal and complicated pregnancies
Note: results are presented as median values (the maximum value ÷ the minimum value); р1 is the р value indicating the difference from the group of healthy nonpregnant women р2 is the р value indicating the difference from the group of healthy pregnant women.
Table 3. Spearman’s correlation between cfDNA concentrations and DNase I activity
Table 4. Levels of cfDNA and DNase I activity in patients with different grades IUGR
Note: results are presented as median values (the maximum value ÷ the minimum value; р1 is the р value indicating the difference from the group of patients with grade I IUGR; р2 is the р value indicating the difference from the group of patients with grade II IUGR; * represents р < 0.01 indicating the difference from the groups of healthy nonpregnant and pregnant women.
