2018 / 04

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DOI: 10.24075/brsmu.2018.041

ORIGINAL RESEARCH

Levels of cell-free DNA and DNAse I activity in complicated and normal pregnancies

Avetisova KG1, Kostyuk SV2, Kostyuk EV2, Ershova ES2, Shmarina GV2, Veiko NN2, Spiridonov DS1, Klimenko PA1, Kurtser MA1
About authors

1 Department of Obstetrics and Gynecology, Faculty of Pediatrics,
Pirogov Russian National Research Medical University, Moscow

2 Laboratory of Molecular Biology, Research Centre for Medical Genetics, Moscow

Correspondence should be addressed: Kristina G. Avetisova
Sevastopol avenue, 24a, Moscow, 117209; ur.xednay@6102avositeva.c

Received: 2018-03-15 Accepted: 2018-06-27 Published online: 2018-09-15
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Table 1. Characteristics of patients with IUGR of the fetus
Note: results are presented as median values (the maximum value ÷ the minimum value); р1 is the р value indicating the difference from the group of pregnant patients with grade I IUGR; р2 is the р value indicating the difference from the group of pregnant patients with grade II IUGR.
Table 2. Concentrations of plasma cfDNA and the activity of DNase I in healthy nonpregnant women and women with normal and complicated pregnancies
Note: results are presented as median values (the maximum value ÷ the minimum value); р1 is the р value indicating the difference from the group of healthy nonpregnant women р2 is the р value indicating the difference from the group of healthy pregnant women.
Table 3. Spearman’s correlation between cfDNA concentrations and DNase I activity
Table 4. Levels of cfDNA and DNase I activity in patients with different grades IUGR
Note: results are presented as median values (the maximum value ÷ the minimum value; р1 is the р value indicating the difference from the group of patients with grade I IUGR; р2 is the р value indicating the difference from the group of patients with grade II IUGR; * represents р < 0.01 indicating the difference from the groups of healthy nonpregnant and pregnant women.