ORIGINAL RESEARCH

Levels of cell-free DNA and DNAse I activity in complicated and normal pregnancies

Avetisova KG1, Kostyuk SV2, Kostyuk EV2, Ershova ES2, Shmarina GV2, Veiko NN2, Spiridonov DS1, Klimenko PA1, Kurtser MA1
About authors

1 Department of Obstetrics and Gynecology, Faculty of Pediatrics,
Pirogov Russian National Research Medical University, Moscow

2 Laboratory of Molecular Biology, Research Centre for Medical Genetics, Moscow

Correspondence should be addressed: Kristina G. Avetisova
Sevastopol avenue, 24a, Moscow, 117209; ur.xednay@6102avositeva.c

Received: 2018-03-15 Accepted: 2018-06-27 Published online: 2018-09-15
|
  1. Mandel P, Metais P. Les acides nucléiques du plasma sanguin chezl'homme. C R Acad Sci Paris 1948; 142: 241–3.
  2. Fleischhacker M, Schmidt B. Circulating nucleic acids (CNAs) and cancer — a survey. Biochimica et biophysica acta. 2007; 1775 (1): 181–232. DOI: 10.1016/j.bbcan.2006.10.001.
  3. Urbanova M, Plzak J, Strnad H, Betka J. Circulating nucleic acids as a new diagnostic tool. Cell Mol Biol Lett. 2010 Jun; 15 (2): 242–59. DOI: 10.2478/s11658-010-0004-6.
  4. Lo YM, Chiu RW. Genomic analysis of fetal nucleic acids in maternal blood. Annu Rev Genomics Hum Genet. 2012; 13: 285–306. DOI: 10.1146/annurev-genom-090711-163806.
  5. Lo YM. Non-invasive prenatal testing using massively parallel sequencing of maternal plasma DNA: from molecular karyotyping to fetal whole-genome sequencing. Reprod Biomed Online. 2013 Dec; 27 (6): 593–8. DOI: 10.1016/j.rbmo.2013.08.008.
  6. Bauer M, Hutterer G, Eder M, Majer S, Leshane E, Johnson KL, et al. A prospective analysis of cell-free fetal DNA concentration in maternal plasma as an indicator for adverse pregnancy outcome. Prenat Diagn, 2006; 26: 831–36. DOI: 10.1002/pd.1513.
  7. Zhong XY, Laivuori H, Livingston JC, Ylikorkala O, Sibai BM, Holzgreve W, et al. Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. Am J Obstet Gynecol, 2001; 184 (3), 414–9. DOI: 10.1067/mob.2001.109594.
  8. Hahn S, Rusterholz C, Hösli I, Lapaire O. Cell-free nucleic acids as potential markers for preeclampsia. Placenta. 2011 Feb; 32 Suppl: 17–20. DOI: 10.1016/j.placenta.2010.06.018.
  9. Al Nakib M, Desbrière R, Bonello N, Bretelle F, Boubli L, Gabert J, et. al. Total and fetal cell-free DNA analysis in maternal blood as markers of placental insufficiency in intrauterine growth restriction. Fetal Diagn Ther. 2009; 26 (1): 24–8. DOI: 10.1159/000236355.
  10. Vejko NN, Bulycheva NV, Roginko OA, Vejko RV, Ershova ES, Kozdoba OA, i dr. Fragmenty transkribiruemoj oblasti ribosomnogo povtora v sostave vnekletochnoj dnk — marker gibeli kletok organizma. Biomedicinskaja himija. 2008; 54 (1): 78–93.
  11. Korzeneva IB, Kostuyk SV, Ershova LS, Osipov AN, Zhuravleva VF, Pankratova GV, et. al. Human circulating plasma DNA significantly decreases while lymphocyte DNA damage increases under chronic occupational exposure to low-dose gamma-neutron and tritium β-radiation. Mutat Res. 2015 Sep; 779: 1–15. DOI: 10.1016/j.mrfmmm.2015.05.004.
  12. Ershova E, Sergeeva V, Klimenko M, Avetisova K, Klimenko P, Kostyuk E, Veiko N, Veiko R, Izevskaya V, Kutsev S, Kostyuk S. Circulating cell-free DNA concentration and DNase I activity of peripheral blood plasma change in case of pregnancy with intrauterine growth restriction compared to normal pregnancy. Biomed Rep. 2017 Oct; 7 (4): 319–24. DOI: 10.3892/br.2017.968.
  13. Sur Chowdhury C, Hahn S, Hasler P, Hoesli I, Lapaire O, Giaglis S. Elevated Levels of Total Cell-Free DNA in Maternal Serum Samples Arise from the Generation of Neutrophil Extracellular Traps. Fetal Diagn Ther. 2016; 40 (4): 263–7. DOI: 10.1159/000444853.
  14. Demidov VN, Bychkov PA, Logvinenko AV, Voevodin SM. Ul'trazvukovaja biometrija. Spravochnye tablicy i uravnenija. V knige: Medvedeva M. V., Zykina B. I., redaktory. Klinicheskie lekcii po UZ-diagnostike v perinatologii. M., 1990; 83–92.
  15. Dement'eva G. M. Ocenka fizicheskogo razvitija novorozhdennyh: posobie dlja vrachej. M., 2000. 25 s.
  16. Ermakov AV, SV Kostyuk, MS Konkova, NA Egolina, EM Malinovskaya, NN Veiko. Extracellular DNA fragments. Annals of the New York Academy of Sciences. 1137 (1): 41–6.
  17. Muñoz-Hernández R, Medrano-Campillo P, Miranda ML, Macher HC, Praena-Fernández JM, Vallejo-Vaz AJ, et. al. Total and Fetal Circulating Cell-Free DNA, Angiogenic, and Antiangiogenic Factors in Preeclampsia and HELLP Syndrome. Am J Hypertens. 2017 Jul 1; 30 (7): 673–82. DOI: 10.1093/ajh/hpx024.
  18. Hahn S, Giaglis S, Buser A, Hoesli I, Lapaire O, Hasler P. Cell-free nucleic acids in (maternal) blood: any relevance to (reproductive) immunologists? J Reprod Immunol. 2014 Oct; 104–105: 26–31. DOI: 10.1016/j.jri.2014.03.007.
  19. Nadeau-Vallée M, Obari D, Palacios J, Brien MÈ, Duval C, Chemtob S, et. al. Sterile inflammation and pregnancy complications: a review. Reproduction. 2016 Dec; 152 (6): R277– R292. Epub 2016 Sep 27.