ORIGINAL RESEARCH

Lipid metabolic changes in rat brain during permanent cerebral ischemia

Kostyuk AI1, Kotova DA1,2, Demidovich AD1,3, Panova AS1, Kelmanson IV1,4, Belousov VV1,4, Bilan DS1
About authors

1 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

2 Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia

3 Lomonosov Moscow State University, Moscow, Russia

4 The Research Institute for Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Dmitry S. Bilan
Miklukho-Maklaya, 16/10, Mosow, 117997; moc.liamg@vosuoleb.dolovesv / moc.liamg@nalib.s.d

About paper

Funding: the work was supported by the Russian Science Foundation Grant 17-15-01175.

Author contribution: Bilan DS and Belousov VV were responsible for the study design and drafting the manuscript; Bilan DS, Kotova DA and Kelmanson IV performed surgeries; Kostyuk AI, Kotova DA, Demidovich AD and Panova AS performed biochemical measurements.

Received: 2018-12-12 Accepted: 2019-02-26 Published online: 2019-03-10
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Fig. 1. Changes of biochemical parameters of brain tissues during permanent ischemia in rats. (A) NAD(H), (B) Total cholesterol, (C) Free fatty acids (FFA), (D) Malondialdehyde (MDA), (E) Glutathione (GSH)