2019 / 01

Next Paper
DOI: 10.24075/brsmu.2019.008

ORIGINAL RESEARCH

Lipid metabolic changes in rat brain during permanent cerebral ischemia

Kostyuk AI1, Kotova DA1,2, Demidovich AD1,3, Panova AS1, Kelmanson IV1,4, Belousov VV1,4, Bilan DS1
About authors

1 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

2 Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia

3 Lomonosov Moscow State University, Moscow, Russia

4 The Research Institute for Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Dmitry S. Bilan
Miklukho-Maklaya, 16/10, Mosow, 117997; moc.liamg@vosuoleb.dolovesv / moc.liamg@nalib.s.d

About paper

Funding: the work was supported by the Russian Science Foundation Grant 17-15-01175.

Author contribution: Bilan DS and Belousov VV were responsible for the study design and drafting the manuscript; Bilan DS, Kotova DA and Kelmanson IV performed surgeries; Kostyuk AI, Kotova DA, Demidovich AD and Panova AS performed biochemical measurements.

Received: 2018-12-12 Accepted: 2019-02-26 Published online: 2019-03-10
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  1. World Health Organization. Top ten causes of death. Available from: http://www.who.int/mediacentre/factsheets/fs310/en/index. html (accessed August 19, 2012).
  2. Hinkle JL, Guanci MM. Acute Ischemic Stroke Review. Journal of Neuroscience Nursing. 2007; 39 (5): 285–93. PubMed PMID: 17966295.
  3. Krzyżanowska W, Pomierny B, Filip M, Pera J. Glutamate transporters in brain ischemia: to modulate or not? Acta Pharmacologica Sinica. 2014; 35 (4): 444–62. PubMed PMID: 24681894.
  4. Berliocchi L, Bano D, Nicotera P. Ca2+ signals and death programmes in neurons. Philos Trans R Soc Lond B Biol Sci. 2005; 360 (1464): 2255–8. PubMed PMID: 16321795.
  5. Klogeris T, Baines CP, Krenz M, Korthuis RJ. Ischemia/ Reperfusion. Compr Physiol. 2016; (7): 113–70 PubMed PMID: 28135002.
  6. Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol. 2012; (298): 229–317. PubMed PMID: 22878108.
  7. Allen CL, Bayraktutan U. Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke. International Journal of Stroke. 2009; 4 (6); 461–70. PubMed PMID: 19930058.
  8. Lesnefsky EJ, Chen Q, Tandler B, Hoppel CL. Mitochondrial dysfunction and myocardial ischemia-reperfusion: implications for novel therapies. Annual review of pharmacology and toxicology. 2017; (57): 535–65. PubMed PMID: 27860548.
  9. Vanden Hoek TL, Li C, Shao Z, Schumacker PT, Becker LB. Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol. 1997; (29): 2571–83. PubMed PMID: 9299379.
  10. Gaschler MM, Stockwell BR. Lipid peroxidation in cell death. Biochem Biophys Res Commun. 2017; 482 (3): 419–25. PubMed PMID: 28212725.
  11. Gaucher C, Boudier A, Bonetti J, Clarot I, Leroy P, Parent M. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants (Basel). 2018; 7 (5): 62. PubMed PMID: 29702624.
  12. Bilan DS, Shohina AG, Lukjanov SA, Belousov VV. Osnovnye redoks-pary kletki. Bioorganicheskaya himija. 2015; (41): 385– 402. Russian.
  13. Dringen R, Pawlowski PG, Hirrlinger J. Peroxide detoxification by brain cells. Journal of Neuroscience Research. 2004; 79 (1–2): 157–165. PubMed PMID: 15573410.
  14. 14. Garcia YJ, Rodrıguez-Malaver AJ, Peñaloza N. Lipid peroxidation measurement by thiobarbituric acid assay in rat cerebellar slices. Journal of Neuroscience Methods. 2005; (144): 127–35. PubMed PMID: 15848246.
  15. Charis WT, Scott MD. Single Extraction Method for the Spectrophotometric Quantification of Oxidized and Reduced Pyridine Nucleotides in Erythrocytes. Analytical Biochemistry. 1994; (222): 417–26. PubMed PMID: 7864367.
  16. Uluc K, Miranpuri A, Kujoth GC, Akture E, Baskaya MK. Focal cerebral ischemia model by endovascular suture occlusion of the middle cerebral artery in the rat. J Vis Exp. 2011 Feb 5; (48). PubMed PMID: 21339721.
  17. Gutteridge JMC, Halliwell B. The measurement and mechanism of lipid peroxidation in biological systems. Trends in Biochemical Sciences. 1990; 15 (4): 129–35. PubMed PMID: 2187293.
  18. Ceconi C, Cargnoni A, Pasini E, Condorelli E, Curello S, Ferrari R. Evaluation of phospholipid peroxidation as malondialdehyde during myocardial ischemia and reperfusion injury. Am J Physiol. 1991; 260 (4 Pt 2): H1057–61. PubMed PMID: 2012211.
  19. Bazаn NG. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochimica et Biophysica Acta (BBA) — Lipids and Lipid Metabolism. 1970; 218 (1): 1–10. PubMed PMID: 5473492.
  20. Braughler JM, Hall ED. Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Radic Biol Med. 1989; (6): 289–301. Pubmed PMID: 266366.
  21. Cojocaru IM, Cojocaru M, Sapira V, Ionescu A. Evaluation of oxidative stress in patients with acute ischemic stroke. Rom J Intern Med. 2013 Apr-Jun; 51 (2): 97–106. Pubmed PMID: 24294813.
  22. Lorente L, Martin MM, Perez-Cejas A, Abreu-Gonzalez P, Ramos L, Argueso M et al. Association between total antioxidant capacity and mortality in ischemic stroke patients. Ann Intensive Care. 2016; 6 (1): 39. Pubmed PMID: 27107565.
  23. Golovko SA, Golovko MI. Plasma Unesterified Fatty-Acid Profile Is Dramatically and Acutely Changed under Ischemic Stroke in the Mouse Model. Lipids. 2018; 52 (6): 641–645. PubMed PMID: 30206953.
  24. Niu Z, Hu H, Tang F. High Free Fatty Acid Levels Are Associated with Stroke Recurrence and Poor Functional Outcome in Chinese Patients with Ischemic Stroke. J Nutr Health Aging. 2017; 21 (10): 1102–1106. PubMed PMID: 29188867.
  25. Wang X, Feng A, Zhu C. Cerebrospinal fluid levels of free fatty acid associated with ischemic stroke recurrence and functional outcome. Neurol Sci. 2016; 37 (9): 1525–9. PubMed PMID: 27245354.