ORIGINAL RESEARCH

A study of the type of antimicrobial action of novel compounds synthesized from substituted benzaminoindoles

Stepanenko IS1, Yamashkin SA2, Kostina YuA1, Slastnikov ED1, Batarsheva AA1
About authors

1 Institute of Medicine, National Research Mordovia State University, Saransk, Russia

2 Evseviev Mordovia State Institute of Pedagogy, Saranks, Russia

Correspondence should be addressed: Irina S. Stepanenko
Ulianova 26, Saranks, 430032; ur.liam@anikhamy

About paper

Author contribution: Stepanenko IS conducted the experiment and analyzed its results; Yamashkin SA helped to design the experiment and synthesized the tested compounds; Kostina YuA analyzed the results of the experiment and wrote the article; Batarsheva AA and Slastnikov ED conducted the experiment.

Received: 2018-11-21 Accepted: 2019-04-07 Published online: 2019-04-22
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The antimicrobial activity of novel compounds is tested by determining the minimum inhibitory concentration of the agent in question and investigating a few other parameters, including the type of antimicrobial action the drug exhibits. The aim of this study was to determine the type of antimicrobial action of the compounds synthesized from the substituted benzaminoindoles. The strain of Staphylococcus aureus АТСС 6538-Р was briefly exposed to the compounds with laboratory codes 5D, 7D, HD, and S3. Bacterial growth was evaluated macroscopically under transmitted light. Additionally, photoelectric colorimetry was applied to monitor changes in the optical density of the culture medium. The minimum inhibitory concentrations of the studied compounds delayed bacterial growth for 2–3 days and had a bacteriostatic effect on S. aureus.

Keywords: antimicrobial activity, benzaminoindole, pyrroloquinoline, antimicrobial activity type

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