ORIGINAL RESEARCH

A study of the type of antimicrobial action of novel compounds synthesized from substituted benzaminoindoles

Stepanenko IS1, Yamashkin SA2, Kostina YuA1, Slastnikov ED1, Batarsheva AA1
About authors

1 Institute of Medicine, National Research Mordovia State University, Saransk, Russia

2 Evseviev Mordovia State Institute of Pedagogy, Saranks, Russia

Correspondence should be addressed: Irina S. Stepanenko
Ulianova 26, Saranks, 430032; ur.liam@anikhamy

About paper

Author contribution: Stepanenko IS conducted the experiment and analyzed its results; Yamashkin SA helped to design the experiment and synthesized the tested compounds; Kostina YuA analyzed the results of the experiment and wrote the article; Batarsheva AA and Slastnikov ED conducted the experiment.

Received: 2018-11-21 Accepted: 2019-04-07 Published online: 2019-04-22
|
  1. Parhizgari N, Gouya MM, Mostafavi E. Emerging and re-emerging infectious diseases in Iran. Iranian Journal of Microbiology. 2017; 9 (3): 122–42.
  2. Yokoyama M, Stevens Е, Laabei М, Bacon L, Heesom K, Bayliss S et al. Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA. Genome Biology. 2018; 19 (1): 94.
  3. Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, Balakrishnan R et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. The Lancet Infectious Diseases. 2010; 10 (9): 597–602.
  4. McKeegan KS, Borges-Walmsley MI, Walmsley AR. Microbial and viral drug resistance mechanisms. Trends in Microbiology. 2002; (10): 8–14.
  5. Savjani JK, Gajjar AK, Savjani KT. Mechanisms of resistance: useful tool to design antibacterial agents for drug — resistant bacteria. Mini-Reviews in Medicinal Chemistry. 2009; 9 (2): 194–205.
  6. Yadav N, Dubey A, Shukla S, Saini CP, Gupta G, Priyadarshini R et al. Graphene Oxide-Coated Surface: Inhibition of Bacterial Biofilm Formation due to Specific Surface-Interface Interactions. ACS Omega. 2017; 2 (7): 3070–82.
  7. Obayiuwana A, Ogunjobi M, Yang M, Ibekwe М. Characterization of Bacterial Communities and Their Antibiotic Resistance Profiles in Wastewaters Obtained from Pharmaceutical Facilities in Lagos and Ogun States. Nigeria International Journal of Environmental Research and Public Health. 2018; 15 (7): 1365.
  8. Kozlov RS. Antibiotic resistance of gram-positive pathogens of complicated intra-abdominal infections in Russia. Clinical microbiology and antimicrobial chemotherapy. 2015; 17 (3): 227–34.
  9. Romanov AV. Antibiotic resistance of nosocomial strains of Staphylococcus aureus in hospitals in Russia: results of the Marathon 2013–2014 multicenter epidemiological study. Clinical microbiology and antimicrobial chemotherapy. 2017; 19 (1): 57–62.
  10. Sukhorukova MV. Antibiotic resistance of nosocomial Enterobacteriaceae strains in hospitals in Russia: the results of the Marathon 2013–2014 multicenter epidemiological study. Clinical microbiology and anti-microbial chemotherapy. 2017; 19 (1): 49–56.
  11. Rasporyazheniye Pravitel'stva RF ot 25 sentyabrya 2017 g. № 2045-r «O strategii preduprezhdeniya rasprostraneniya antimikrobnoy rezistentnosti v RF na period do 2030 g.». Available from: https://www.garant.ru/products/ipo/prime/doc/71677266/. Russian.
  12. Alyamkina EA, Stepanenko IS, Yаmashkin SA, Yurovskaya MA. Soedineniya s potencial'noj antimikrobnoj aktivnost'yu na osnove 4-amino-2-fenilindola. Vestnik Moskovskogo universiteta. 2016; 57 (6): 410–7. Russian.
  13. Alyamkina ЕА, Yamashkin SA, Stepanenko IS, Yurovskaya MA. 4-amino-2-phenylindole-based compounds with potential antibacterial activity. Moscow University Chemistry Bulletin. 2017; 72 (1): 24–8.
  14. Stepanenko IS. A new group of compounds derived from 4-, 5-, 6- and 7-aminoindoles with antimicrobial activity. Research Results in Pharmacology. 2018; 4 (3): 17–26.
  15. Pershin GN, redaktor. Prakticheskoe rukovodstvo. Metody ehksperimental'noj himioterapii. M.: Medicina, 1971; 541 s. Russian.
  16. Mironov AN, Bunyatyan ND, Vasilyev AN, Verstakova OL, Zhuravleva VV, Lepakhin VK, i dr. Rukovodstvo po provedeniju doklinicheskih issledovanij lekarstvennyh sredstv. M.: Grif i K, 2012; 944 s. Russian.
  17. Opredelenie chuvstvitel'nosti mikroorganizmov k antibakterial'nym preparatam. Metodicheskie ukazanija MUK 4.2.1890-04. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija. 2004; 6 (4): 303–402. Russian.
  18. Kozlov RS, Sukhorukova MV, Eidelstein MV, Ivanchik NV, Skleenova EYu, Timokhova AV, et al. Determination of the sensitivity of microorganisms to antimicrobial drugs: clinical recommendations. Smolensk: Interregional Association of Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 206 p.