Author contribution: Zhorina YuV — conceived and planned the study, collected, processed and interpreted the data, performed statistical analysis, participated in writing the manuscript; Abramovskikh OS — proposed the method and supervised the study, analyzed and interpreted the data, participated in writing the manuscript; Ignatova GL — analyzed the clinical data, supervised the study, interpreted the data, participated in writing the manuscript; Ploshchanskay OG — collected the data, conducted laboratory tests, interpreted the data and participated in writing the manuscript.