Funding: this work would not have been published without the generous support and the strict publication requirements of the Russian Foundation for Basic Research grant 18-04-01173. KSS is supported by the president fellowship 075-15-2019-411. Experiments were partially carried out using the equipment provided by the Institute of Bioorganic Chemistry of the Russian Academy of Sciences Сore Facility (CKP IBCH; supported by Russian Ministry of Education and Science Grant RFMEFI62117X0018).

Acknowledgements: we thank to the Center for Precision Genome Editing and Genetic. Technologies for Biomedicine (Moscow) for the genetic research methods.

Author contribution: Sarkisyan KS, Gorbachev DA — conceived and planned the project, performed the experiments, analysed data and prepared the manuscript.