Acknowledgements: the authors thank Ovsyannikov VG, Head of the Department of Pathologic Physiology (Rostov State Medical University) and Boychenko AE, Professor at the Department of Pathologic Physiology, for their valuable advice and feedback; Aboyan IA, Chief Physician of the Clinical Diagnostic Center Health, for granting access to the laboratory equipment of the Center.

Author contribution: Alexeev VV conducted the experiment, analyzed and interpreted the obtained results, wrote the manuscript; Kade AKh conceived and designed the study, revised the manuscript for intellectual content and made final corrections.