2020 / 01

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DOI: 10.24075/brsmu.2020.008

ORIGINAL RESEARCH

The role of some xenobiotic biotransformation genes SNP in the development of acute pancreatitis

Samgina TA, Nazarenko PM, Polonikov AV, Lazarenko VA
About authors

Kursk State Medical University, Kursk, Russia

Correspondence should be addressed: Tatiana A. Samgina
K. Marksa, 3, 305000; Kursk, ur.tsil@ssat

About paper

Author contribution: Samgina TA conceived and designed the study, conducted clinical and molecular-genetic tests, analyzed and interpreted the obtained data, and wrote the manuscript; Nazarenko PM supervised surgical treatment and postoperative care at Kursk City Clinical Hospital № 4 and recruited patients for the study; Polonikov AV supervised genetic testing; Lazarenko VA supervised the study.

Received: 2020-01-05 Accepted: 2020-02-08 Published online: 2020-02-16
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Table 1. The analysis of the associations between the risk of AP and the alleles/genotypes of the polymorphic genes encoding the enzymes involved in xenobiotic biotransformation and antioxidant defense (the codominant model)
Table 2. The impact of alcohol abuse on the development of AP in the presence of alcohol-induced pancreatitis in the carriers of the studied polymorphisms
Note: interp — significance threshold in the analysis of interactions between SNPs and the risk factor; the risk factor (f+)3 is long-term alcohol abuse (over 10 years).
Table 3. The analysis of the associations between the risk of infected pancreatic necrosis and the genotypes of the studied polymorphisms (the most significant models)
Table 4. The analysis of the associations between the risk of pancreatic pseudocysts in patients with AP and the genotypes of the studied polymorphisms (the most significant model)
Table 5. The analysis of the associations between the risk of peripancreatic necrosis and the genotypes of the studied polymorphisms (the most significant model)