ORIGINAL RESEARCH

The role of some xenobiotic biotransformation genes SNP in the development of acute pancreatitis

Samgina TA, Nazarenko PM, Polonikov AV, Lazarenko VA
About authors

Kursk State Medical University, Kursk, Russia

Correspondence should be addressed: Tatiana A. Samgina
K. Marksa, 3, 305000; Kursk, ur.tsil@ssat

About paper

Author contribution: Samgina TA conceived and designed the study, conducted clinical and molecular-genetic tests, analyzed and interpreted the obtained data, and wrote the manuscript; Nazarenko PM supervised surgical treatment and postoperative care at Kursk City Clinical Hospital № 4 and recruited patients for the study; Polonikov AV supervised genetic testing; Lazarenko VA supervised the study.

Received: 2020-01-05 Accepted: 2020-02-08 Published online: 2020-02-16
|
  1. Setiawan VW, Pandol SJ, Porcel J, Wilkens LR, Le Marchand L, Pike MC, et al. Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. Pancreas. 2016; 45 (6): 819–25.
  2. Ali UA, Issa Y, Hagenaars JC, Bakker OJ, van Goor H, Nieuwenhuijs VB, Schaapherder AF. Risk of recurrent pancreatitis and progression to chronic pancreatitis after a first episode of acute pancreatitis. Clinical gastroenterology and hepatology. 2016; 14 (5): 738–46.
  3. Mrozikiewicz-Rakowska B, Malinowski M, Nehring P, Bartkowiak- Wieczorek J, Bogacz A, Żurawińska-Grzelka E, et al. The MDR1/ ABCB1 gene rs 1045642 polymorphism in colorectal cancer. Archives of Medical Science. 2017; 13 (1).
  4. Zhao L, Li K, Li W, Yang Z. Association between the C3435T polymorphism of ABCB1/MDR1 gene (rs1045642) and colorectal cancer susceptibility. Tumor Biology. 2013; 34 (3): 1949–57.
  5. Vinnik YuS, Cherdancev DV, Markova EV, Konovalenko AN, Pervova OV, Miller MS. Geneticheskie aspekty pankreatita. Sibirskij medicinskij zhurnal (Irkutsk). 2004; 43 (2). Russian.
  6. Hosagrahara VP, Rettie AE, Hassett C, Omiecinski CJ. Functional analysis of human microsomal epoxide hydrolase genetic variants. Chem Biol Interact. 2004; (150): 149–59.
  7. Wang X, Cheung CM, Lee WY, Or PM, Yeung JH. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine. 2010; 17 (11): 868–75.
  8. Kim MS, Lee DH, Kang HS, Park HS, Jung S, Lee JW, et al. Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis. Korean J Gastroenterol. 2004; (43): 355–63.
  9. Frenzer A, Butler WJ, Norton ID, Wilson JS, Apte MV, Pirola RC, et al. Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol- induced cirrhosis and chronic pancreatitis. J Gastroenterol Hepatol. 2002; (17): 177–82.
  10. Yang B, O'Reilly DA, Demaine AG, Kingsnorth AN. Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis. Alcohol. 2001; (23): 91–7.
  11. Burim RV, Canalle R, Martinelli Ade L, Takahashi C. Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Mutagenesis. 2004; (19): 291–8.
  12. Natalskij AA, Bogomolov AYu, Andrianova KV. Polimorfizm genov u bol'nyh hronicheskim pankreatitom. V sbornike: Teorija i praktika sovremennoj hirurgii: Materialy X Vserossijskoj konferencii obshhih hirurgov; Rjazan', 2018; s. 219–220. Russian.
  13. Smithies AM, Sargen K, Demaine AG, Kingsnorth AN. Investigations of the interleukin 1 gene cluster and its association with acute pancreatitis. Pancreas. 2000; 20 (3): 234–40.
  14. Teich N, Bauer N, Mössner J, Keim V. Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants. The American journal of gastroenterology. 2002; 97 (2): 341–6.
  15. Ulrich AB, Standop J, Schmied BM, Schneider MB, Lawson TA, Pour PM. Species differences in the distribution of drug- metabolizing enzymes in the pancreas. Toxicologic pathology. 2002; 30 (2): 247–53.
  16. Dellinger EP, Forsmark CE, Layer P, Levy P, Maravi-Poma E, Petrov MS, et al. Determinant-based classification of acute pancreatitis severity: an international multidisciplinary consultation. Ann Surg. 2012; 256 (6): 875–80.
  17. Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013; 62 (1): 102–11.
  18. Klyaritskaya IL, Rabotyagova YuS. Novye faktory riska razvitija hronicheskogo pankreatita. Krymskij terapevticheskij zhurnal. 2012; (2): 63–69. Russian.
  19. Lazarenko VA, Antonov AE. Sovremennoe sostojanie problemy vrednyh privychek kak faktora riska razvitija pankreatita. Social'nye aspekty zdorov'ja naselenija. 2017; 55 (3). Russian.
  20. Furtwængler NA, de Visser RO. Lack of international consensus in low‐risk drinking guidelines. Drug and alcohol review. 2013; 32 (1): 11–18.
  21. Baranov VS, Baranova EV, Ivashhenko TYe, Aseev MV. Genom cheloveka i geny «predraspolozhennosti»: vvedenie v prediktivnuju medicinu. SPb.: Intermedika, 2000; 271 s. Russian.
  22. Spicyn VA, Makarov SV, Paj GV, Bychkovskaja LS. Polimorfizm v genah cheloveka, associirujushhihsja s biotransformaciej ksenobiotikov. Vestnik VOGiS. 2006; 10 (1): 97–105. Russian.
  23. Hubacek JA, Zakharov S. Response to ‘CYP2E1 Polymorphism and Better Outcome After Methanol Poisoning’. Basic and clinical pharmacology and toxicology. 2015; 117 (1): 3–4.
  24. Marzolini C, Paus E, Buclin T, Kim RB. Polymorphisms in human MDR1 (P‐glycoprotein): recent advances and clinical relevance. Clinical Pharmacology and Therapeutics. 2004; 75 (1): 13–33.
  25. Guo HQ, Zhang GN, Wang YJ, Zhang YK, Sodani K, Talele T, Chen ZS. β-Elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter. Oncology reports. 2014; 31 (2): 858–66.
  26. Sychev DA, Levanov AN, Shelekhova TV, Bochkov PO, Denisenko NP, Ryzhikova KA, Kozlov AV. The impact of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) gene polymorphisms on dabigatran equilibrium peak concentration in patients after total knee arthroplasty. Pharmacogenomics and Personalized Medicine. 2018; (11): 127.
  27. Sychev D, Shikh N, Morozova T, Grishina E, Ryzhikova K, Malova E. Effects of ABCB1 rs1045642 polymorphisms on the efficacy and safety of amlodipine therapy in Caucasian patients with stage I–II hypertension. Pharmacogenomics and personalized medicine. 2018; (11): 157.