ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Immunohistochemical expression of Nanog protein in prostate cancer cells of distinct grade groups
About authors
1 Peoples’ Friendship University of Russia, Moscow, Russia
2 Research Institute of Human Morphology, Moscow, Russia
3 Hospital for War Veterans № 2, Moscow, Russia
Correspondence should be addressed: Georgy Yu. Kudryavtsev
Baikalskaya, 35, apt. 216, Moscow, 107207; ur.liam@ahsogk
About paper
Compliance with ethical standards: the study was approved by the Ethics Committee of Medical Institute of the Peoples' Friendship University of Russia (protocol № 13 dated December 19, 2019); the study design was consistent with the Declaration of Helsinki guidelines regarding the research involving identifiable human tissue samples. The informed consent was submitted by all patients.
Author contribution: Kudryavtsev GYu, Kudryavtsevа YaYu, Solovyeva NA — literature survey, manuscript writing; Kudryavtseva LV, Osipov VA — statistical data processing; Mikhaleva LM — sample collection and processing; Babichenko II — study concept and design.
Received: 2020-10-06
Accepted: 2020-10-20
Published online: 2020-10-31
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Fig. 1. Expression of Ki-67 in patients with benign prostatic hyperplasia and prostate adenocarcinoma
Fig. 2. Comparison of Ki-67 expression between different prostate cancer Grade Groups
Fig. 3. Comparison of Nanog expression between different prostate cancer Grade Groups
Fig. 4. Expression of Ki-67 and Nanog in the prostate cancer cells for the most common Gleason patterns (magnification х400)
Table. Relationship between the expression of Ki-67 and Nanog and the major clinical and morphological characteristics
