Funding: the study was supported by the Ministry of Science and Higher Education of the Russian Federation, project ID RFMEFI61719X0056.

Acknowledgement: the authors express their appreciation to the Center for Collective Use "Human Proteome" (IBMC) for the opportunity to use the equipment for proteome analysis, and to the Center for Precision Genome Editing and Genetic Technologies for Biomedicine of the Pirogov Russian National Research Medical University (Moscow, Russia) for the opportunity to use the molecular biology technologies.

Author contribution: Maltseva DV — working with cultured cells, molecular biology research, data analysis, manuscript writing; Poloznikov AA — proteomic and transcriptomic analysis data processing, bioinformatics analysis, functional analysis of genes, statistical analysis, manuscript writing, study management; Artyushenko VG — interpreting the study results, manuscript reviewing.

Compliance with ethical standards: the study was carried out in accordance with the World Medical Association Declaration of Helsinki.