Funding: the study involving p53 gene knockdown, ELISA and PCR tests was performed as part of the Fundamental Scientific Research Programs of the State Academies of Sciences for 2013–2020; experiments with Nutlin-3a were carried out by RMA “Perspektiva” and supported by RFBR, project № 18-44-540031/19.

Author contribution: Luzgina NG, Rusanov AL — study concept; Romashin DD, Kozhin PM, Luzgina NG, Rusanov AL — study design and literature analysis; Romashin DD, Kozhin PM, Karagyaur MN — study planning and execution; Kozhin PM, Romashin DD, Luzgina NG, Rusanov AL — data analysis and interpretation; Kozhin PM, Romashin DD — manuscript writing; Kozhin PM, Romashin DD, Karagyaur MN, Luzgina NG, Rusanov AL — manuscript editing, preparation of the final version of the article.

Compliance with ethical standards: the study was carried out in accordance with the World Medical Association Declaration of Helsinki.