ORIGINAL RESEARCH

Local antioxidant effect of original dermal film with melatonin in thermal injury

Osikov MV1, Simonyan EV1, Ageeva AA1, Ageev YuI1, Fedosov AA2, Sinitsky AI1
About authors

1 South-Ural State Medical University, Chelyabinsk, Russia

2 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Anna A. Ageeva
Vorovskogo, 64, Chelyabinsk, 454092; ur.xednay@r.aveega.enna

About paper

Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University, Chelyabinsk (Minutes #10 of November 15, 2019), carried out in standard vivarium conditions with strict adherence to the requirements for animal keeping and care, as well as withdrawal of animals from the experiment and subsequent disposal in accordance with the European Convention for the Protection of Vertebrate Animals used for Experimental or Other Scientific Purposes (ETS № 123 of March 18, 1986, Strasbourg), EC Recommendations 2007/52/EC of June 18, 2007 outlining procedures of keeping and care for animals used for experimental and other scientific purposes, as well as the European Parliament and EU Council Directive 2010/63/EU of September 22, 2010 on protection of animals used for scientific purposes as governed by the rules of humane treatment of animals, guidelines for their withdrawal from experiments and euthanasia.

Author contribution: MV Osikov — study concept and design, integrated analysis of the data obtained, authoring, manuscript editing; EV Simonyan — experimental material collection, analysis of the data obtained; AA Ageeva — experimental material collection, statistical processing and analysis of the data obtained, authoring; YuI Ageev — experimental material collection, statistical processing and analysis of the data obtained; AA Fedosov — analysis of the results, manuscript editing; AI Sinitsky — experimental material collection, manuscript editing.

Received: 2020-10-03 Accepted: 2020-10-23 Published online: 2020-11-11
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  1. Statisticheskij sbornik 2018 god. Social'no-znachimye zabolevanija naselenija Rossii v 2018 godu. 2019; 11: 69. Dostupno po ssylke: https://www.rosminzdrav.ru/ministry/61/22/stranitsa-979/ statisticheskie-i-informatsionnye-materialy/statisticheskiy-sbornik- 2018-god. Russian.
  2. Li H, Yao Z, Tan J, et al. Epidemiology and outcome analysis of 6325 burn patients: a five-year retrospective study in a major burn center in Southwest China. Sci Rep. 2017; 7: 46066. DOI: 10.1038/srep46066.
  3. Abdullahi A, Jeschke MG. Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions. Endocrine Reviews. 2017; 38 (6): 538–49.
  4. Gęgotek A, Skrzydlewska E. Biological effect of protein modifications by lipid peroxidation products. Chemistry and Physics of Lipids. 2019; 221: 46–52. DOI: 10.1016/j. chemphyslip.2019.03.011.
  5. Valacchi G, Virgili F, Cervellati C, Pecorelli A. OxInflammation: From Subclinical Condition to Pathological Biomarker. Front Physiol. 2018; 9: 858. DOI: 10.3389/fphys.2018.00858.
  6. Hawkins CL, Davies MJ. Detection, identification, and quantification of oxidative protein modifications. Journal of Biological Chemistry. 2019; 294 (51): 19683–708.
  7. Murray RZ, West ZE, Cowin AJ, Farrugia BL. Development and use of biomaterials as wound healing therapies. Burns Trauma. 2019; 7: 2. DOI: 10.1186/s41038-018-0139-7.
  8. Osikov MV. Vlijanie jeritropojetina na processy svobodno-radikal'nogo okislenija i jekspressiju glikoproteinov v trombocitah pri hronicheskoj pochechnoj nedostatochnosti. Bjulleten' jeksperimental'noj biologii i mediciny. 2014; 157 (1): 30–33. Russian.
  9. Osikov MV, Telesheva LF, Ageev YuI. Vlijanie jeritropojetina na apoptoz limfocitov pri jeksperimental'noj hronicheskoj pochechnoj nedostatochnosti. Bjulleten' jeksperimental'noj biologii i mediciny. 2015; 3: 326–9. Russian.
  10. Osikov MV. Rol' orozomukoida v reguljacii aktivnosti sistem plazmennogo proteoliza pri jeksperimental'noj pochechnoj nedostatochnosti. Bjulleten' jeksperimental'noj biologii i mediciny. 2009; 7: 27–30. Russian.
  11. Osikov MV, Telesheva LF, Ageev YI. Antioxidant effect of erythropoietin during experimental chronic renal failure. Bulletin of Experimental Biology and Medicine. 2015; 160 (2): 202–4.
  12. Varoni EM, Soru C, Pluchino R, Intra C, Iriti M. The Impact of Melatonin in Research. Molecules. 2016; 21 (2): 240. DOI: 10.3390/molecules21020240.
  13. Volchegorskij IA, Nalimov AG, Yarovinskij VG. Sopostavlenie razlichnyh podhodov k opredeleniju produktov POL v geptan-izopropanol'nyh jekstraktah krovi. Voprosy medicinskoj himii. 1989; 35 (1): 127–31. Russian.
  14. Fomina MA, Abalenihina YuV. Sposob kompleksnoj ocenki soderzhanija produktov okislitel'noj modifikacii belkov v tkanjah i biologicheskih zhidkostjah: metodicheskie rekomendacii. GBOU VPO RjazGMU Minzdrava. Rjazan': RIO RjazGMU, 2014. Russian.
  15. Mitran MI, Nicolae I, Tampa M, Mitran CI, Caruntu C, Sarbu MI, et al. Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis. Metabolites. 2019; 9 (10): E213. DOI: 10.3390/metabo9100213.
  16. Wei C, Ding X, Liu C, Pei Y, Zhong Y, Sun W. Mechanism of taurine in alleviating myocardial oxidative stress in rats after burn through p38 MAPK signaling pathway. Minerva Med. 2019; 110 (5): 472–75.
  17. Jacob S, Herndon DN, Hawkins HK, Enkhbaatar P, Cox RA. Xanthine oxidase contributes to sustained airway epithelial oxidative stress after scald burn. International journal of burns and trauma. 2017; 7 (6): 98–106.
  18. Klein GL. The role of the musculoskeletal system in post-burn hypermetabolism. Metabolism. 2019; 97: 81–86.
  19. ErginTuncay M, Erkılıc A, Gunes A, Nural C, Erel O. A remarkable point for evaluating the severity of burns: Thiol-disulfide profile. Burns. 2019; 46 (4): 0305-4179(19)30638-2. DOI: 10.1016/j. burns.2019.10.013.
  20. Lee YH, Bang ES, Lee JH, Lee JD, Kang DR, Hong J, Lee JM. Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients. Biological Trace Element Research. 2019; 188 (2): 316–25.
  21. Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M. Biology and Biomarkers for Wound Healing. Plastic and Reconstructive Surgery. 2016; 138 (3): 18–28.
  22. Lee HJ, Jang YJ. Recent. Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids. International Journal of Molecular Sciences. 2018; 19 (3): 711. DOI: 10.3390/ijms19030711.
  23. Yu H, Dickson EJ, Jung SR, Koh DS, Hille B. High membrane permeability for melatonin. The Journal of General Physiology. 2016; 147: 63–76.
  24. Mayo JC, Aguado A, Cernuda-Cernuda R, Alvarez-Artime A, Cepas V, Quiros-Gonzalez I, et al. Melatonin uptake by cells: an answer to its relationship with glucose? Molecules. 2018; 23: e1999. DOI: 10.3390/molecules23081999.
  25. Janjetovic Z, Jarrett SG, Lee EF, Duprey C, Reiter RJ, Slominski AT. Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways. Scientific Reports. 2017; 7 (1): 1274. DOI: 10.1038/s41598-017- 01305-2.
  26. Rusanova I, Martínez-Ruiz L, Florido Ja, Rodríguez-Santana C, Guerra-Librero A, Acuña-Castroviejo D, et al. Protective Effects of Melatonin on the Skin: Future Perspectives. International Journal of Molecular Sciences. 2019; 20 (19): 4948. DOI: 10.3390/ ijms20194948.
  27. Dai J, Choo MK, Park JM, Fisher DE. Topical ROR inverse agonists suppress inflammation in mouse models of atopic dermatitis and acute irritant dermatitis. Journal of Investigative Dermatology. 2017; 137: 2523–31.
  28. Slominski AT, Semak I, Fischer TW, Kim TK, Kleszczyński K, Hardeland R, et al. Metabolism of melatonin in the skin: Why is it important? Experimental Dermatology. 2017; 26: 563–8.
  29. Janjetovic Z, Jarrett SG, Lee EF, Duprey C, Reiter RJ, Slominski AT. Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways. Scientific Reports. 2017; 7 (1): 1274. DOI: 10.1038/s41598-017- 01305-2.
  30. Reiter RJ, Rosales-Corral S, Tan DX, Jou MJ, Galano A, Xu B. Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideas. Cellular and Molecular Life Sciences. 2017; 74 (21): 3863–81.