ORIGINAL RESEARCH
Interrelation between miRNA and mRNA expression in HT-29 line cells under hypoxia
1 National Research University Higher School of Economics, Moscow, Russia
2 Lomonosov Moscow State University, Moscow, Russia
3 Moscow Center for Fundamental and Applied Mathematics, Moscow, Russia
4 Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia
Correspondence should be addressed: Diana V. Maltseva
Vavilova, 7, Moscow, 117321; moc.liamg@avestlamd
Funding: the work was supported financially by the Russian Science Foundation (agreement #17-14-01338).
Compliance with ethical standards: the study was approved by the Ethics Committee of Amur State Medical Academy (Protocol № 10 dated November 20, 2019); the study conformed with the guidelines for the medical research involving human subjects. Voluntary informed consent was obtained from all the participants.
Author contribution: SA Nersisyan and AV Galatenko — sequencing data processing, bioinformatic analysis, functional gene analysis, building the regulatory network of interactions, manuscript preparation; DV Maltseva — cell culturing work, preparation of samples for sequencing, manuscript preparation for publication; YA Ushkaryov — discussion of the results, article text review; AG Tonevitsky — research organization, analysis of the results, article manuscript preparation.