ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2022 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Alleviation of neurological and cognitive impairments in rat model of ischemic stroke by 0.5 MAC xenon exposure
About authors
1 Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia
2 Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
3 Sechenov First Moscow State Medical University, Moscow, Russia
4 Sklifosovsky Institute for Emergency Medicine, Moscow, Russia
Correspondence should be addressed: Rostislav A. Cherpakov
B. Cherkizovskaya, 6, korp. 6, k. 36, Moscow, 107061, Russia
About paper
Funding: the study was funded by the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology state budgetary institution of science as a part of research project "Anesthetic neuroprotection with xenon and sevoflurane in severe brain damage. Clinical and experimental study" (No. 0427-2019-0035).
Author contribution: Krukov IA — study design, concept development and research algorithm establishment; Ershov AV — experimental part, statistical analysis of the data; Cherpakov RA — manuscript writing and editing; Grebenchikov OA — scientific editing of the final version.
Compliance with ethical standards: the study was approved by Ethical Review Board at the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology (Protocol № 4/21/2 of 29 September 2021) and conducted in compliance with the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (ETS № 123, Strasbourg 18/03/1986, with the Appendix of 2006), Guide for the Care and Use of Laboratory Animals, 8th ed. (2010), Directive 2010/63/EU of the European Parliament and the Council on the Protection of Animals Used for Scientific Purposes (2010) and the Good Laboratory Practice Guidelines (2016).
Received: 2022-05-21
Accepted: 2022-06-12
Published online: 2022-06-24
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Table. Alleviation of neurological and cognitive impairments by 0.5 MAC xenon exposure of varying time length, Ме (LQ; HQ)
Note: SO — sham-operated animals; ^ — significant differences compared to sham-operated animals (р < 0.05; Mann–Whitney test); * — significant differences compared to the control group (р < 0.05; Mann–Whitney test).
