ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2022 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Systemic inflammation markers of diet-induced metabolic syndrome in rat model
About authors
Siberian State Medical University, Tomsk, Russia
Correspondence should be addressed: Julia G. Birulina
Moskovsky Trakt, 2, str. 7, Tomsk, 634050, Russia; ur.xednay@02anilurib
About paper
Funding: the study was supported by the Russian Science Foundation, Grant № 22-25-20039, https://rscf.ru/project/22-25-20039/ and funds of the Tomsk Region Administration.
Author contribution: Birulina JG, Voronkova OV — concept and design, manuscript writing; Ivanov VV, Buyko EE — metabolic syndrome modeling, biochemical blood tests; Shcherbakova MM — blood cytokine assay; Chernyshov NA — literature analysis, hemogram tests; Motlokhova EA — statistical analysis.
Compliance with ethical standards: the study was approved by Ethical Review Board at SibSMU (Protocol № 8201 of 27 March 2020) and carried out in compliance with humanity principles stated in the 86/609 EEC Directive and the Declaration of Helsinki.
Received: 2022-08-11
Accepted: 2022-08-25
Published online: 2022-08-30
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Table 1. Physiological parameters and biochemical markers of metabolic syndrome in rats
Note: The data are given as M ± SD; AUC0–120 is the area under curve of glucose concentration on time (glucose tolerance test); р-values characterize experimental vs control group comparisons.
Table 2. Hematological parameters for experimental and control groups
Note: The data are given as Me (Q25; Q75); р-values characterize experimental vs control group comparisons.
Table 3. Blood cytokine levels for experimental and control groups
Note: The data are given as Me (Q25; Q75); р-values characterize experimental vs control group comparisons.
