Frequent association of vitiligo with autoimmune endocrine diseases: primary data of the Russian cohort of adult patients

Nuralieva NF1, Yukina MYu1, Troshina EA1, Zhukova OV2,3, Petrov VA2, Volnukhin VA2
About authors

1 Endocrinology Research Centre, Moscow, Russia

2 Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia

3 Peoples’ Friendship University of Russia, Moscow, Russia

Correspondence should be addressed: Nurana F. Nuralieva
Dmitriya Ulyanova, 11, Moscow, 117292, Russia; ur.xednay@anarunn

About paper

Funding: this work was supported by Foundation for Scientific and Technological Development of Yugra (agreement No 2022-05-01/2022).

Author contribution: Nuralieva NF — endocrinology examination, data acquisition, statistical analysis, literature analysis, manuscript writing, preparation of the article for publication; Yukina MYu — study concept development, endocrinology examination, manuscript editing; Troshina EA — approval of the study concept and the final text of the manuscript; Zhukova OV — approval of the final text of the manuscript; Petrov VA — dermatology examination, data acquisition, literature analysis; Volnukhin VA — approval of the study concept, dermatology examination, manuscript editing and approval of the final text.

Compliance with ethical standards: the study was approved by the Ethics Commitee of the Endocrinology Research Centre (protocol № 17 of 27 September 2017); the informed consent was submitted by all patients.

Received: 2022-09-29 Accepted: 2022-10-13 Published online: 2022-10-29

There is evidence in the literature about more frequent association of vitiligo with autoimmune endocrine diseases (AEDs) compared to general population. No full-fledged studies aimed at assessing the prevalence of AEDs in the Russian cohort of adult vitiligo patients have been conducted. The study was aimed to assess the prevalence of AEDs in the cohort of Russian adult vitiligo patients. Patients with vitiligo monitored in two clinics, the  Endocrinology Research Centre (Clinic 1; n = 39) and the Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology  (Clinic 2; n = 26), were enrolled. Along with clinical examination, screening laboratory tests were performed in all patients in order to reveal AEDs. The majority of patients (more than 95% of cases) had nonsegmental vitiligo. Among patients monitored in Clinic 1, AEDs were diagnosed in 85% of cases: isolated AEDs accounted for 39%, while multiple AEDs were found in 46% of cases. Autoimmune thyroid diseases were diagnosed in 69% of cases. Autoimmune adrenal insufficiency was found in 28% of patients, type 1 diabetes mellitus in 21%, hypoparathyroidism in 13%, hypergonadotropic hypogonadism in 10%, endocrine ophthalmopathy in 10% of patients. Among patients monitored in Clinic 2, AEDs were diagnosed in four patients (15% of cases): three patients had primary hypothyroidism in the outcome of autoimmune thyroiditis, one patient had Graves' disease. Thus, the prevalence of AEDs in patients with vitiligo may vary between 15–85%. Vitiligo is most often associated with autoimmune thyroid diseases (15–69%). Vitiligo patients should undergo annual screening aimed at detection of autoimmune endocrine disorders, especially thyroid diseases.

Keywords: vitiligo, autoimmune thyroiditis, type 1 diabetes mellitus, Graves' disease, autoimmune adrenal insufficiency, autoimmune polyglandular syndrome, prevalence