2022 / 06

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DOI: 10.24075/brsmu.2022.060

ORIGINAL RESEARCH

Gut microbiota alterations in patients with juvenile idiopathic arthritis

Porosyuk MV, Klementiev DD, Hodov NA, Gumenyuk LN, Esatova ES, Sereda EV, Chetveruhina-Malova KS, Sarchuk EV, Ivanov SV
About authors

Georgievsky Medical Academy, Vernadsky Crimean Federal University, Simferopol, Russia

Correspondence should be addressed: Lesya Nikolaevna Gumenyuk
Lenina bulvar, 5/7, Simferopol, 295006, Republic of Crimea; ur.liam@kuynemyg_aysel

About paper

Author contribution: Porosyuk MV, Klementiev DD — data acquisition, analysis, and interpretation; Gumenyuk LN — study concept and design; Hodov NA, Esatova ES, Sereda EV — statistical data processing; Chetveruhina-Malova KS, Sarchuk EV, Ivanov SV — manuscript writing

Compliance with ethical standards: the study was approved by the Ethics Committee of the S.I. Georgievsky Medical Academy, V. I. Vernadsky Crimean Federal University (protocol № 10 of 16 November 2020), planned and conducted in accordance with the Declaration of Helsinki. The infirmed consent was submitted by all the subjects enrolled.

Received: 2022-11-01 Accepted: 2022-11-29 Published online: 2022-12-19
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Fig. 1. Comparative analysis of the gut microbiota phylogenetic composition in patients with juvenile idiopathic arthritis and healthy children. JIA — juvenile idiopathic arthritis, CG — control group
Fig. 2. Comparative analysis of the gut microbiota genus-level taxonomic composition in patients with JIA and healthy children. JIA — juvenile idiopathic arthritis, CG — control group
Table 1. Characteristics of patients with JIA and healthy children
Table 2. Clinical characteristics of patients with juvenile idiopathic arthritis
Note: Anti-CCP — anti–cyclic citrullinated peptide (anti-CCP) antibody
Table 3. Comparative analysis of cortisol, melatonin and TNFα levels in blood plasma of patients with JIA and healthy children
Note: р — significance of differences between the JIA group and the control group.