ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Gut microbiota alterations in patients with juvenile idiopathic arthritis
About authors
Georgievsky Medical Academy, Vernadsky Crimean Federal University, Simferopol, Russia
Correspondence should be addressed: Lesya N. Gumenyuk
Lenina bulvar, 5/7, Simferopol, 295006, Republic of Crimea; ur.liam@kuynemyg_aysel
About paper
Author contribution: Porosyuk MV, Klementiev DD — data acquisition, analysis, and interpretation; Gumenyuk LN — study concept and design; Hodov NA, Esatova ES, Sereda EV — statistical data processing; Chetveruhina-Malova KS, Sarchuk EV, Ivanov SV — manuscript writing
Compliance with ethical standards: the study was approved by the Ethics Committee of the S.I. Georgievsky Medical Academy, V. I. Vernadsky Crimean Federal University (protocol № 10 of 16 November 2020), planned and conducted in accordance with the Declaration of Helsinki. The infirmed consent was submitted by all the subjects enrolled.
Received: 2022-11-01
Accepted: 2022-11-29
Published online: 2022-12-19
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Fig. 1. Comparative analysis of the gut microbiota phylogenetic composition in patients with juvenile idiopathic arthritis and healthy children. JIA — juvenile idiopathic arthritis, CG — control group
Fig. 2. Comparative analysis of the gut microbiota genus-level taxonomic composition in patients with JIA and healthy children. JIA — juvenile idiopathic arthritis, CG — control group
Table 1. Characteristics of patients with JIA and healthy children
Table 2. Clinical characteristics of patients with juvenile idiopathic arthritis
Note: Anti-CCP — anti–cyclic citrullinated peptide (anti-CCP) antibody
Table 3. Comparative analysis of cortisol, melatonin and TNFα levels in blood plasma of patients with JIA and healthy children
Note: р — significance of differences between the JIA group and the control group.
