Author contribution: Porosyuk MV, Klementiev DD — data acquisition, analysis, and interpretation; Gumenyuk LN — study concept and design; Hodov NA, Esatova ES, Sereda EV — statistical data processing; Chetveruhina-Malova KS, Sarchuk EV, Ivanov SV — manuscript writing

Compliance with ethical standards: the study was approved by the Ethics Committee of the S.I. Georgievsky Medical Academy, V. I. Vernadsky Crimean Federal University (protocol № 10 of 16 November 2020), planned and conducted in accordance with the Declaration of Helsinki. The infirmed consent was submitted by all the subjects enrolled.