2022 / 06

Next Paper
DOI: 10.24075/brsmu.2022.060
Copyright: © 2022 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Gut microbiota alterations in patients with juvenile idiopathic arthritis

Porosyuk MV, Klementiev DD, Hodov NA, Gumenyuk LN, Esatova ES, Sereda EV, Chetveruhina-Malova KS, Sarchuk EV, Ivanov SV
About authors

Georgievsky Medical Academy, Vernadsky Crimean Federal University, Simferopol, Russia

Correspondence should be addressed: Lesya N. Gumenyuk
Lenina bulvar, 5/7, Simferopol, 295006, Republic of Crimea; ur.liam@kuynemyg_aysel

About paper

Author contribution: Porosyuk MV, Klementiev DD — data acquisition, analysis, and interpretation; Gumenyuk LN — study concept and design; Hodov NA, Esatova ES, Sereda EV — statistical data processing; Chetveruhina-Malova KS, Sarchuk EV, Ivanov SV — manuscript writing

Compliance with ethical standards: the study was approved by the Ethics Committee of the S.I. Georgievsky Medical Academy, V. I. Vernadsky Crimean Federal University (protocol № 10 of 16 November 2020), planned and conducted in accordance with the Declaration of Helsinki. The infirmed consent was submitted by all the subjects enrolled.

Received: 2022-11-01 Accepted: 2022-11-29 Published online: 2022-12-19
|
  1. Rigante D, Bosco A, Esposito S. The Etiology of Juvenile Idiopathic Arthritis. Clin Rev Allergy Immunol. 2015; 49 (2): 25361. DOI: 10.1007/s12016-014-8460-9.
  2. Shiff NJ, Oen K, Kroeker K, Lix LM. Trends in populationbased incidence and prevalence of juvenile idiopathic arthritis in Manitoba, Canada. Arthritis Care Res. 2019; 71 (3): 413–8.
  3. Gumenyuk LN, Kabatova IN. Osobennosti kachestva zhizni bol'nyx yuvenil'nym revmatoidnym artritom na sanatornokurortnom lechenii. Tavricheskiĭ mediko-biologicheskiĭ vestnik. 2017; 20 (2): 32–35. Russian.
  4. Raghavendra VV, Singh AV, Shaji H Vohra, Kulkarni SK, Agrewala JN. Melatonin provides signal 3 to unprimed CD4(+) T cells but failed to stimulate LPS primed B cells. Clin Exp Immunol. 2001; 124: 414–22.
  5. Fedorov ES, Salugina SO, Kuzmina NN. Rol' citokinovoj seti v regulyacii vospaleniya pri razlichnyx variantax yuvenil'nogo artrita. 2009; 3: 74–89. Russian.
  6. Belyaeva LM, Chizhevskaya ID, Filonovich RM, i dr. Sovremennye podxody k terapii revmaticheskix boleznej u detej. Mezhdunarodnyj zhurnal pediatrii, akusherstva i ginekologii. 2013; 3 (3): 25–34. Russian.
  7. Kabatova IN. Sostoyanie gormonal'nogo komponenta adaptacii u deteĭ s yuvenil'nym revmatoidnym artritom. Tavricheskii ̆ mediko-biologicheskiĭ vestnik. 2017; 20 (3): 43–48. Russian.
  8. Skoromnaya NN. Rol' ehpifizarnogo gormona melatonina v regulyacii razlichnyx zven'ev ehndokrinnoj sistemy u bol'nyx yuvenil'nym revmatoidnym artritom. Zdorov'e rebenka. 2012; 8 (43): 65–70. Russian.
  9. Qian X, Liu YX, Ye X, et al. Gut microbiota in children with juvenile idiopathic arthritis: characteristics, biomarker identification, and usefulness in clinical prediction. BMC Genomics. 2020; 21: 286.
  10. Di Paola M, Cavalieri D, Albanese D, et al. Alteration of fecal microbiota profiles in juvenile idiopathic arthritis. Associations with HLA-B27 allele and disease status. Front Microbiol. 2016; 7: 1703.
  11. Tejesvi MV, Arvonen M, Kangas SM, et al. Faecal microbiome in new-onset juvenile idiopathic arthritis. Eur J Clin Microbiol Infect Dis. 2016; 35 (3): 363–70.
  12. Zhang X, Zhang D, Jia H, et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med. 2015; 21 (8): 895–905.
  13. Pianta A, Arvikar S, Strle К, et al. Evidence of the immune relevance of Prevotella copri, a gut microbe, in patients with rheumatoid arthritis. Arthritis Rheumatol. 2017; 69 (5): 964–75.
  14. Manfredo Vieira S, Hiltensperger M, Kumar V, et al. Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science. 2018; 359 (6380): 1156–61.
  15. Berntson L. A pilot study of possible anti-inflammatory effects of the specific carbohydrate diet in children with juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2021; 19 (1): 88.
  16. Ashworth A. Nutrition, food security, and health. In: Kliegman RM, Stanton BF, St Geme III JW, Schor NF, editors. Nelson textbook of pediatrics. 20th ed. New York: Elsevier, 2015.
  17. Gahagan S. Overweight and obesity. In: Kliegman RM, Stanton BF, St Geme III JW, Schor NF, editors. Nelson textbook of pediatrics. 20th ed. New York: Elsevier, 2015; 307–16.
  18. Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004; 31: 390–2.
  19. Smolen JS, Breedveld FC, Eberl G, et al. Validity and reliability of the twenty-eight-joint count for the assessment of rheumatoid arthritis activity. Arthritis Rheum. 1995; 38: 38–43.
  20. Mitra S, Forster-Fromme K, Damms-Machado A,. et al. Analysis of the intestinal microbiota using SOLiD16S rRNA gene sequencing and SOLiD shotgun sequencing. BMC Genomics. 2013; 14 (5): 16.
  21. Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010; 7 (5): 335–6.
  22. DeSantis TZ, Hugenholtz P, Larsen N. Greengenes, a chimerachecked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol. 2006; 72: 5069–72.
  23. Ritari J, Salojärvi J, Lahti L, de Vos WM. Improved taxonomic assignment of human intestinal 16S rRNA sequences by a dedicated reference database. BMC Genomics. 2015; 16 (1): 1056.
  24. Vinolo MAR, Rodrigues HG, Nachbar RT, Curi R. Regulation of Inflammation by Short Chain Fatty Acids. Nutrients. 2011; 3 (10): 858–76.
  25. Stoll ML, Weiss PF, Weiss JE, et al. Age and fecal microbial strainspecific differences in patients with spondyloarthritis. Arthritis Res Ther. 2018; 20 (1): 14.
  26. Breban M, Tap J, Leboime A, et al. Faecal microbiota study reveals specific dysbiosis in spondyloarthritis. Ann Rheum Dis. 2017; 76 (9): 1614–22.
  27. Tito RY, Cypers H, Joossens M, et al. Brief report: dialister as a microbial marker of disease activity in Spondyloarthritis. Arthritis Rheumatol. 2017; 69 (1): 114–21.
  28. Sanna S, van Zuydam NR, Mahajan A, et al. Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nat Genet. 2019; 51 (4): 600–5.
  29. Michels N, Van de Wiele T, Fouhy F, et al. Gut microbiome patterns depending on children's psychosocial stress: Reports versus biomarkers. Brain Behav Immun. 2019; 80: 751–62.
  30. Rosin S, Xia K, Azcarate-Peril MA, et al. A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants. Psychoneuroendocrinology. 2021; 124: 105046.
  31. Dalile B, Vervliet B, Bergonzelli G, et al. Colon-delivered shortchain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlledtrial. Neuropsychopharmacol. 2020; 45: 2257–66.
  32. Van de Wouw M, Boehme M, Lyte JM, et al. Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain– gut axis alterations. J Appl Physiol. 2018; 596: 4923–44.
  33. Ziegler DR, Herman JP. Neurocircuitry of stress integration: anatomical pathways regulating the hypothalamo-pituitaryadrenocortical axis of the rat1. Integr Comp Biol. 2002; 42: 541–51.
  34. Song L, He M, Sun Q, et al. Roseburia hominis Increases Intestinal Melatonin Level by Activating p-CREB-AANAT Pathway. Nutrients. 2022;14:117.
  35. Huang X, Qiu Y, Gao Y, et al. Gut microbiota mediate melatonin signalling in association with type 2 diabetes. Diabetologia. 2022; 65 (10): 1627–41.
  36. Henke MT, Kenny, DJ, Cassilly CD, et al. Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide. Proc Natl Acad Sci. 2019; 116: 12672–7.