2022 / 06

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DOI: 10.24075/brsmu.2022.066

ORIGINAL RESEARCH

Transgenic mice for study of the CDK8/19 cyclin-dependent kinase kinase-independent mechanisms of action

Stavskaya NI1, Ilchuk LA2, Okulova YuD2, Kubekina MV2, Varlamova EA2, Silaeva YY1, Bruter AV2
About authors

1 Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia

2 Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia

Correspondence should be addressed: Leonid A. Ilchuk
Prospekt Mira, 124, Moscow, 129164, Russia; moc.liamg@21kuhcel

About paper

Funding: RSF grant, project № 22-15-00227.

Author contribution: Stavskaya NI ― experimental procedure, working with animals; Ilchuk LA ― manuscript writing, design of genotyping systems, data analysis; Okulova YuD ― working with embryos; Kubekina MV ― preparation of genetically engineered construct, experimental procedure; Varlamova EA ― experimental procedure; Silaeva YuYu ― literature analysis, study planning; Bruter AV ― literature analysis, study planning, data analysis and interpretation, manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Commitee of the Institute of Gene Biology RAS (protocol No. 1 of 10 November 2021) and conducted in full compliance with the Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes.

Received: 2022-11-22 Accepted: 2022-12-19 Published online: 2022-12-28
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