Metabolic engineering is a promising way to generate highly effective producers of bioactive substances

Blokhina AE1,2, Palkina KA1, Shakhova ES1, Malyshevskaia AK1,2, Osipova ZM1,3, Myshkina NM1
About authors

1 Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

2 Lomonosov Moscow State University, Moscow, Russia

3 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Nadezhda M. Myshkina
Miklukho-Maklaya, 16/10, Moscow, 117997, Russia; moc.liamg@aydan.anikram

About paper

Funding: the study was supported by the Russian Science Foundation Grant № 21-74-00075, https://rscf.ru/project/21-74-00075/

Acknowledgements: the authors would like to thank A.S. Sheglov, research fellow at the Laboratory of Chemistry of Metabolic Pathways, for valuable criticisms.

Author contribution: Blokhina AE, Palkina KA, Shakhova ES, Malyshevskaia AK, Osipova ZM — literature review, data processing; Myshkina NM — literature review, data processing, project management, manuscript writing.

Received: 2023-04-05 Accepted: 2023-04-19 Published online: 2023-04-26

Medicines play an indisputable role in life extension and improvement of the quality of life. To obtain medicinal compounds, researchers traditionally rely on natural sources and chemical synthesis, however, currently developing biotechnological methods allow one to introduce the group of genes encoding new metabolic pathways into the genomes of heterologous hosts and regulate activity of the hosts' intrinsic metabolic pathways. Such an approach makes it possible to reproduce biosynthesis of bioactive substances in heterologous hosts, the approach combines the benefits of conventional methods and works around the shorcomings of those. In our view, the use of metabolic engineering to obtain medicinal compounds is becoming increasingly important for their production.

Keywords: metabolic pathways, heterologous gene expression, metabolic engineering, biosynthesis of medicinal compounds