2023 / 03

Next Paper
DOI: 10.24075/brsmu.2023.018

ORIGINAL RESEARCH

Gut microbiota alterations and their association with IL6, IL8 and TNFα levels in patients with external genital endometriosis

Gumenyuk LN, Zemlyanaya IA, Rami A, Badula ES, Ismailov AR, Seroshtanov NA, Kokareva SS, Cheremisova AA, Kupreichyuk YuR
About authors

SI Georgievsky Medical Academy, VI Vernadsky Crimean Federal University, Simferopol, Russia

Correspondence should be addressed: Lesya Nikolaevna Gumenyuk
Bulvar Lenina, 5/7295006, Simferopol, Republic of Crimea, Russia; ur.liam@anikoros.ayel

About paper

Author contribution: Gumenyuk LN — study concept and design; Zemlyanaya IA, Rami A, Seroshtanov NA — data acquisition, analysis, and interpretation; Badula ES, Ismailov AR — statistical data processing; Kokareva SS, Cheremisova AA, Kupreichyuk YuR — manuscript writing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the SI Georgievsky Medical Academy, VI Vernadsky Crimean Federal University (protocol № 10 of 14 November 2021), planned and conducted in accordance with the Declaration of Helsinki. The informed consent was obtained from all study participants.

Received: 2023-01-13 Accepted: 2023-05-15 Published online: 2023-06-15
|
  1. Zondervan KT, Becker CM, Koga K, Missmer SA, Taylor RN, Viganò P. Endometriosis. Nat Rev Dis Primers. 2018; 4: 9.
  2. Saunders PTK, Horne AW. Endometriosis: Etiology, pathobiology, and therapeutic prospects. Cell. 2021; 184 (11): 2807–24.
  3. Bao C, Wang H, Fang H. Genomic Evidence Supports the Recognition of Endometriosis as an Inflammatory Systemic Disease and Reveals Disease-Specific Therapeutic Potentials of Targeting Neutrophil Degranulation. Front Immunol. 2022; 23 (13): 758440.
  4. Greene R, Stratton P, Cleary SD, Ballweg ML, Sinaii N. Diagnostic experience among 4,334 women reporting surgically diagnosed endometriosis. Fertility and sterility. 2009; 91 (1): 32–39.
  5. Greenbaum H, Bat-El L, Galper BEL, Decter DH, Eisenberg VH. Endometriosis and autoimmunity: Can autoantibodies be used as a non-invasive early diagnostic tool? Autoimmun Rev. 2021; 20 (5): 102795.
  6. Clement Philip B. The Pathology of Endometriosis: A Survey of the Many Faces of a Common Disease Emphasizing Diagnostic Pitfalls and Unusual and Newly Appreciated Aspects. Advances in Anatomic Pathology. 2007; 14 (4): 241–60.
  7. Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet. 2021; 27: 839–52.
  8. Yarmolinskaya MI. Citokinovyĭ profil' peritoneal'noĭ zhidkosti i perifericheskoĭ krovi bol'nyh s naruzhnym genital'nym ehndometriozom. Zhurnal akusherstva i zhenskih boleznei. 2008; ̆ 57 (3): 30–34. Russian.
  9. Sikora J, Smycz-Kubanska M, Mielczarek-Palacz A, Kondera-́ Anasz Z. Abnormal peritoneal regulation of chemokine activation — the role of IL8 in pathogenesis of endometriosis. American Journal of Reproductive Immunology. 2017; 77 (4).
  10. Cameron MJ, Kelvin DJ. Cytokines and chemokines — their receptors and their genes: an overview. Advances in Experimental Medicine and Biology. 2003; 520: 8–32.
  11. Somigliana E, Viganò P, Tirelli AS, Felicetta I, Torresani E, Vignali M, et al. Use of the concomitant serum dosage of CA 125, CA 19-9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions. Human Reproduction. 2004; 19 (8): 1871–6.
  12. Dong Hao Lu, Song H, Shi G. Anti-TNFα treatment for pelvic pain associated with endometriosis. Cochrane database of systematic reviews. 2010; 3 (3): CD008088.
  13. Li A, Dubey S, Varney ML, Dave BJ, Singh RK. IL8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. Journal of Immunology. 2003; 170 (6): 3369–76.
  14. Malvezzi H, Hernandes C, Piccinato CA, Podgaec S. Interleukin in endometriosis-associated infertility-pelvic pain: systematic review and meta-analysis. Reproduction. 2019; 158 (1): 1–12.
  15. Scholl B, Bersinger NA, Kuhn A. Correlation between symptoms of pain and peritoneal fluid inflammatory cytokine concentrations in endometriosis. Gynecol Endocrinol. 2009; 25 (11): 701–6.
  16. Wu HJ, Wu E. The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes. 2012; 3 (1): 4–14.
  17. Chadchan SB, Cheng M, Parnell LA, Yin Y, Schriefer A, Mysorekar IU, et al. Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota. Hum Reprod. 2019; 34: 1106–16.
  18. Chadchan SB, Naik SK, Popli P, et al. Gut microbiota and microbiota-derived metabolites promotes endometriosis. Cell Death Discov. 2023; 9: 28.
  19. Chadchan SB, Popli P, Ambati CR, Tycksen E, Han SJ, Bulun SE, et al. Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis. Life Sci Alliance. 2021; 30; 4 (12): e202101224.
  20. Ni Z, Sun S, Bi Y, Ding J, Cheng W, Yu J, et al. Correlation of fecal metabolomics and gut microbiota in mice with endometriosis. Am J Reprod Immunol. 2020; 84: e13307.
  21. Svensson A, Brunkwall L, Roth B, Orho-Melander M, Ohlsson B. Associations Between Endometriosis and Gut Microbiota. Reprod Sci. 2021; 28 (8): 2367–77.
  22. Chen S, Gu Z, Zhang W, Jia S, Wu Y, Zheng P, et al. The study of endometriosis and adenomyosis related microbiota in female lower genital tract in Northern Chinese population. Gynecology and Obstetrics Clinical Medicine. 2021; 1 (3): 119–29.
  23. Ser H-L, Au Yong S-J, Shafiee MN, Mokhtar NM, Ali RAR. Current updates on the role of microbiome in endometriosis: a narrative review. Microorganisms. 2023; 11 (2): 360.
  24. Mitra S, Förster-Fromme K, Damms-Machado A, Scheurenbrand T, Biskup S, Huson, DH, et al. Analysis of the intestinal microbiota using SOLiD16S rRNA gene sequencing and SOLiD shotgun sequencing. BMC Genomics. 2013; 14 (5): 16.
  25. Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010; 7 (5): 335–6.
  26. DeSantis TZ, Hugenholtz P, Larsen N. Greengenes, a chimerachecked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol. 2006; 72: 5069–72.
  27. Ritari J, Salojärvi J, Lahti L, de Vos WM. Improved taxonomic assignment of human intestinal 16S rRNA sequences by a dedicated reference database. BMC Genomics. 2015; 16 (1): 1056.
  28. Vallejo V, Ilagan JG. A Postpartum Death Due to Coronavirus Disease 2019 (COVID-19) in the United States. ObstetGynecol. 2020; 136 (1): 52–55.
  29. Kumari R, Ahuja V, Jaishree P. Fluctuations in butyr-ate-producing bacteria in ulcerative colitis patients of North India. World J Gastroenterol. 2013; 19: 3404–14.
  30. Ata B, Yildiz S, Turkgeldi E, Brocal VP, Dinleyici EC, Moya A, et al. The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls. Sci Rep. 2019; 9 (1): 2204.
  31. Kodati VL, Govindan S, Movva S, Ponnala S, Hasan Q. Role of Shigella infection in endometriosis: a novel hypothesis. Med Hypotheses. 2008; 70 (2): 239–43.
  32. Gumenyuk LN, Golod MV, Silaeva NV, Sorokina LE, Ilyasov SS, Androschyuk NA, et al. Gut microbiota alterations and their relationship to the disease severity and some cytokine profile indicators in patients with COVID-19. Bulletin of RSMU. 2022; 1: 22–9.
  33. Liu P, Gao M, Liu Z, Zhang Y, Tu H, Lei L, et al. Gut microbiome composition linked to inflammatory factors and cognitive functions in first-episode, drug-naive major depressive disorder patients. Front Neurosci. 2022; 28 (15): 800764.
  34. Shan J, Ni Z, Cheng W, Zhou L, Zhai D, Sun S, et al. Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis. Arch Gynecol Obstet. 2021; 304: 1363–73.
  35. Philpott DJ, Yamaoka S, Israël A, Sansonetti PJ. Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharidedependent innate intracellular response and leads to IL8 expression in epithelial cells. J Immunol. 2000; 165 (2): 903–14.
  36. Raqib R, Wretlind B, Andersson J, Lindberg AA. Cytokine secretion in acute shigellosis is correlated to disease activity and directed more to stool than to plasma. J Infect Dis. 1995; 171: 376–384.
  37. Kim SJ, Choi EY, Kim EG, Shin SH, Lee JY, Choi JI, et al. Prevotella intermedia lipopolysaccharide stimulates release of tumor necrosis factor-alpha through mitogen-activated protein kinase signaling pathways in monocyte-derived macrophages. FEMS Immunol Med Microbiol. 2007; 51 (2): 407–13.