Author contribution: Gumenyuk LN — study concept and design; Zemlyanaya IA, Rami A, Seroshtanov NA — data acquisition, analysis, and interpretation; Badula ES, Ismailov AR — statistical data processing; Kokareva SS, Cheremisova AA, Kupreichyuk YuR — manuscript writing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the SI Georgievsky Medical Academy, VI Vernadsky Crimean Federal University (protocol № 10 of 14 November 2021), planned and conducted in accordance with the Declaration of Helsinki. The informed consent was obtained from all study participants.