ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2023 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Apoptosis of granulosa cells in women with impaired reproductive function and extragenital pathology
About authors
1 Volgograd State Medical University of the Ministry of Health of the Russian Federation, Volgograd, Russia
2 Innovative Medicines R&D and Piloting Center, Volgograd, Russia
3 Department of Assisted Reproductive Technologies. Multidisciplinary Clinic No. 1, Volgograd, Russia
Correspondence should be addressed: Danil S. Lipov
Vysokaya, 18a, Volgograd, 400127, Russia; ur.xednay@vopillinad
About paper
Author contribution: LN Rogova — study planning, data analysis and interpretation; DS Lipov — manuscript authoring, analysis of the study data; VN Perfilova, MV Kustova — determination of the level of apoptosis in granulosa cells by flow cytometry; AV Mukhina — collection of the granulosa cell samples from patients; DA Churzin — analysis of the published papers, statistical processing of the obtained data.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Volgograd State Medical University (Minutes № 2021/053 of May 27, 2021) and conducted in compliance with the ethics principles of the WMA Declaration of Helsinki (2000). All donors have voluntarily signed the participant consent forms.
Received: 2023-05-12
Accepted: 2023-06-07
Published online: 2023-06-17
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Fig. Research design
Table 1. Living granulosa cells and apoptosis in them as registered in the study subgroups. 1 — F, Fisher's test used for statistical analysis; 2 — Kruskal-Wallis test used for statistical analysis
Table 2. Results of ART treatment of the study participants. 1 — F, Fisher's test used for statistical analysis; 2 — Kruskal-Wallis test used for statistical analysis
