ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Noninvasive preimplantation genetic testing for aneuploidy
About authors
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
Correspondence should be addressed: Olga I. Lisitsyna
Akademika Oparina, 4, Moscow, 117997, Russia; ur.xobni@avokyzay_o
About paper
Funding: the study was supported by the Russian Foundation for Basic Research under research project №23-25-00346.
Author contribution: Makarova NP, Lisitsyna OI, Dolgushina NV — study concept and design; Lisitsyna OI, Makarova NP, Dolgushina NV, Syrkasheva AG, Ekimov AN — manuscript writing and editing; Lisitsyna OI — statistical processing of the results; Goryainova EG, Makarova NP — biomaterial collection; Ekimov AN, Atapina EE — laboratory phase; Dolgushina NV, Trofimov DYu — publication approval.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (protocol № 10 of 28 October 2021). The patients submitted the informed consent to study participation.
Received: 2023-06-18
Accepted: 2023-08-09
Published online: 2023-08-30
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Fig. 1. An example of “heteroploid” niPGT-A result
Fig. 2. Results of the embryo PGT–A and niPGT–A showing discordance between the PGT–A and niPGT–A data: the upper curve shows aneuploidy based on the PGT-A data, the lower curve shows euploidy based on the niPGT-A data.
Fig. 3. An example of full concordance of the results based on the PGT-A and niPGT-A data
Table 1. Results of the studied embryos’ PGT–A and niPGT–A
Table 2. Comparison of the rates of full and clinical concordance between the PGT-A and niPGT-A results based on the binomial test data
