Funding: the study was supported by the Russian Foundation for Basic Research under research project №23-25-00346.

Author contribution: Makarova NP, Lisitsyna OI, Dolgushina NV — study concept and design; Lisitsyna OI, Makarova NP, Dolgushina NV, Syrkasheva AG, Ekimov AN — manuscript writing and editing; Lisitsyna OI — statistical processing of the results; Goryainova EG, Makarova NP — biomaterial collection; Ekimov AN, Atapina EE — laboratory phase; Dolgushina NV, Trofimov DYu — publication approval.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (protocol № 10 of 28 October 2021). The patients submitted the informed consent to study participation.