2023 / 06

DOI: 10.24075/brsmu.2023.053

ORIGINAL RESEARCH

NEAT1_1 long non-coding RNA reduces the survival of primary neuronal cells under ER-stress

Pukaeva NE1,2, Zalevskaya VN2, Deykin AV3, Taubinskaya MI2, Kukharskaya OA2, Ovchinnikov RK1,2, Antohin AI1, Kukharsky MS1,2
About authors

1 Pirogov Russian National Research Medical University, Moscow, Russia

2 Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia

3 Belgorod State National Research University, Belgorod, Russia

Correspondence should be addressed: Michail S. Kukharsky
Ostrovitianova, 1/9, Moscow, 117997, Russia; ur.umsr@myksrahkuk

About paper

Funding: The study was supported by the Russian Science Foundation, Project No. 22-25-00645.

Acknowledgements: Authors would like to express their gratitude to FRC PCP MC RAS Сollective Use Center (FFSN-2021-0005 (2021 – 2023) for providing the opportunity to conduct experiments using laboratory animals.

Author contribution: Pukaeva NE — cell culture experiments, apoptosis data analysis, Zalevskaya VN — cell culture experiments, Deykin AV — generating transgenic mice, Taubinskaya MI — cell culture experiments, neuron morphology analysis, Kukharskaya OA — cell culture experiments, cell death analysis, Ovchinnikov RK — data analysis, manuscript writing, Antohin AI — manuscript editing, Kukharsky MS — study design, data analysis, manuscript writing and editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the FRC PCP MC RAS (Protocol № 53 dated December 18, 2020); animal experimental work was carried out in accordance with the Rules of Good Laboratory Practice in the Russian Federation (2016).

Received: 2023-11-08 Accepted: 2023-12-16 Published online: 2023-12-31
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