ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
OPINION
Potential of non-traditional cell cultures for production of biotherapeutic proteins
About authors
1 Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia
2 Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia
3 Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Zinaida Mikhailovna Osipova
Miklukho-Maklaya, 16/10, Moscow, 117997; ur.hcbi@avoksakz
About paper
Funding: the work was supported by the Russian Science Foundation grant No. 21-74-10152, https://rscf.ru/project/21-74-10152/
Acknowledgements: the authors thank A.D. Barykin from the Department of Bioorganic Chemistry of the Institute of Bioorganic Chemistry of the Russian Academy of Sciences for the fruitful discussion of the idea of this publication.
Author contribution: Dobronos MA — literature search and analysis, manuscript authoring; Osipova ZM — project management, manuscript editing; Markina NM — manuscript idea, literature search and analysis, manuscript authoring.
Received: 2024-04-20
Accepted: 2024-05-12
Published online: 2024-06-13
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Production of biotherapeutic drugs in mammalian cells, recombinant proteins in particular, may be handicapped by the limitations imposed on the cultures by metabolic burden. An alternative solution is to produce proteins in cells of other animals (e.g., Sf9, S2 and High Five insect cell lines, Caenorhabditis elegans and Schistosoma mansoni cell line) or orthogonal cell systems, including plant-based. In our opinion, non-traditional cell cultures may become promising tool for production of affordable and effective biotherapeutic drugs.
Keywords: biotherapeutic drugs, plant cell cultures, metabolic burden, High Five cell line, Sf9 cell line