ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Genetic portraits of Khanty and Mansi based on the Y chromosome haplogroups in the context of gene pools of Russia
About authors
Research Centre for Medical Genetics, Moscow, Russia
Correspondence should be addressed: Georgy Yu. Ponomarev
Moskvorechie, 1, 115522, Moscow, Russia; moc.liamg@009i62ts
About paper
Funding: State Assignment of the Ministry of Science and Higher Education of the Russian Federation for the Research Centre for Medical Genetics.
Acknowledgements: the authors would like to thank all participants of the expedition survey (donors of samples) and Biobank of North Eurasia for access to DNA collections.
Author contribution: Balanovska EV — management; Agdzhoyan AT — contribution to the expedition survey of Ob Ugrians; Ponomarev GYu — Y-SNP marker genotyping; Ponomarev GYu, Potanina AYu, Adamov DS — statistical and cartographic analysis, manuscript formatting; Balanovska EV, Ponomarev GYu — study design and manuscript writing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Centre for Medical Genetics (protocol No. 1 dated 29 June 2020).
Received: 2024-09-09
Accepted: 2024-10-01
Published online: 2024-10-28
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Fig. 1. Gene pool composition and the sites, where the samples of Mansi and various groups of Khanty were originate. Northern Mansi were surveyed in the Beryozovsky district of KhMAO and around, along the Sosva and Lyapin rivers (ancestors in the direct male line were born in villages of Beryozovo, Sosva, Vanzetur, Karym, Kimkyasui, Lombovozh, Verkhniye, Novinskaya, Nyaksimvol, Saranpaul, Khulimsunt, Patrasui, Rakhtynia, Sartynia, Khanglytur, Shhekurya, Yasunt, Unyugan, as well as the sites of Mansi settlements). Khanty were surveyed in the Beloyarsky (n = 32), Beryozovsky (n = 27), Surgutsky (n = 5), and Nizhnevartovsky (n = 19) districts of KhMAO
Fig. 2. Genetic portraits of the Ob Ugrians and surrounding indigenous peoples of the Ural region and Western Siberia. The haplogroup name is provided in the inner ring, while the outer ring provides markers determining the haplogroup; the outer ring division into sectors shows the sub-haplogroup frequency in the population. The color of each Y chromosome haplogroup is specified in the map key.
Fig. 3. Gene geography of the Y chromosome haplogroup N2 major branches: western branch Y3195 of the haplogroup N2 (А) and eastern branch VL67 of the haplogroup N2 (B)
Fig. 4. Phylogenetic structure of the Ural-Siberian cluster N3a4 and frequency of distinct lineages in the populations of Khanty and Mansi. The numbers provided under the names of the branches represent their age in thousands of years ago (kya); the 95% confidence intervals are provided in the text
Fig. 5. Geographical distribution and frequency of the haplogroup N3a4 sub-branches. А. Gene geography of the haplogroup N3a4 branch Y13850. B. Gene geography of the haplogroup N3a4 branch L1034. C. Gene geography of the haplogroup N3a4 branch Y28540*. D. Gene geography of the haplogroup N3a4 branch Y28544
Fig. 6. Position of the Ob Ugrians in the genetic space of surrounding peoples of Russia. А. Multidimensional scaling plot based on the standard panel of 38 Y-chromosomal markers (stress coefficient = 0.14; alienation coefficient = 0.16). B. Multidimensional scaling plot based on the extended panel of 48 Y-chromosomal markers (stress coefficient = 0.16; alienation coefficient = 0.17). The peoples speaking languages of the Uralic linguistic family are highlighted in pink; those belonging to the Turkic branch of the Altaic language family are highlighted in blue
Table 1. Frequencies (%) of Y chromosome haplogroups in the gene pools of Khanty and Mansi
Note: the gradient from minimum to maximum frequencies is highlighted in shades of red and pink: the more intense the cell color, the higher the frequency
Table 2. Pattern of genetic distances between the Ob Ugrians and surrounding peoples of Russia
