Copyright: © 2024 by the authors. Licensee: Pirogov University.
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ORIGINAL RESEARCH

Comparative analysis of the results of testing cervical epithelial samples and cervical biopsy specimens for HPV

Bayramova GR, Trofimov DYu, Andreev AO, Burmenskaya OV, Asaturova AV, Piven VD
About authors

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Correspondence should be addressed: Gyuldana R. Bayramova
Akademika Oparina, 4B, Moscow, 117513, Russia; ur.liam@avomaryab

About paper

Funding: the study was conducted within the framework of the State Assignment No. 124040300006-2 “Development of a test system to detect early signs of cervical and endometrial cancer based on epigenetic DNA analysis in cervical smears”.

Acknowledgements: the authors would like to thank A.R. Zaretsky, head of the Laboratory of Molecular Oncogenetics, Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, for valuable comments on the study concept and analysis of the results.

Author contribution: Bayramova GR, Trofimov DYu — study concept and design; Andreev AO, Bourmenskaya OV — data acquisition and processing; Asaturova AV, Bourmenskaya OV — statistical data processing; Andreev AO, Piven VD — manuscript writing; Bayramova GR, Asaturova AV — manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (protocol No. 11 dated 25 November 2021) and conducted in full compliance with the requirements for confidentiality of personal dara, ethical standards and principles of conducting medical studies involving humans stated in the Declaration of Helsinki of the World Medical Association “Ethical principles for medical research involving human subjects”.

Received: 2024-12-13 Accepted: 2024-12-26 Published online: 2024-12-31
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  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71 (3): 209–49. DOI: 10.3322/caac.21660.
  2. Kyrgiou M, Mitra A, Moscicki AB. Does the vaginal microbiota play a role in the development of cervical cancer? Translational Research. 2017; 179: 168–82. DOI: 10.1016/j.trsl.2016.07.004.
  3. Plisko O, Zodzika J, Jermakova I, Pcolkina K, Prusakevica A, Liepniece-Karele I, et al. Prediction of high-grade cervical precancerous abnormalities: The role of personal factors, vaginal microflora, sexually transmitted infections, and high-risk human papillomavirus. PLoS One. 2024; 19 (11): e0313004. DOI: 10.1371/journal.pone.0313004.
  4. Gravitt PE. The known unknowns of HPV natural history. J Clin Invest. 2011; 121 (12): 4593–9. DOI: 10.1172/JCI57149.
  5. Adams AK, Wise-Draper TM, Wells SI. Human papillomavirus induced transformation in cervical and head and neck cancers. Cancers (Basel). 2014; 6 (3): 1793–820. DOI: 10.3390/cancers6031793.
  6. Khumalo PG, Carey M, Mackenzie L, Sanson-Fisher R. Cervical cancer screening knowledge and associated factors among Eswatini women: A cross-sectional study. PLoS One. 2024; 19 (4): e0300763. DOI: 10.1371/journal.pone.0300763. PMID: 38635684; PMCID: PMC11025751.
  7. Hu H, Wu Y, Zhao M, Liu J, Xie P. Sleep duration time and human papillomavirus infection risk: The U-shaped relationship revealed by NHANES data. PLoS One. 2024; 19 (4): e0301212. DOI: 10.1371/journal.pone.0301212.
  8. Gomes FC, Galhardo DDR, Navegante ACG, Santos GSD, Dias HAAL, Dias Júnior JRL et al. Bioinformatics analysis to identify the relationship between human papillomavirus-associated cervical cancer, toll-like receptors and exomes: A genetic epidemiology study. PLoS One. 2024; 19 (8): e0305760. DOI: 10.1371/journal.pone.0305760.
  9. Scott-Wittenborn N, Fakhry C. Epidemiology of HPV Related Malignancies. Semin Radiat Oncol. 2021; 31 (4): 286–96. DOI: 10.1016/j.semradonc.2021.04.001.
  10. Huiyun J, Jie D, Huan W, Yuebo Y, Xiaomao L. Prevalence and characteristics of cervical human papillomavirus genotypes and cervical lesions among 58630 women from Guangzhou, China. J Infect Public Health. 2023; 16 (10): 1531–6. DOI: 10.1016/j.jiph.2023.07.013. Epub 2023 Jul 21. PMID: 37562080.
  11. Guo M, Sneige N, Silva EG, Jan YJ, Cogdell DE, Lin E, et al. Distribution and viral load of eight oncogenic types of human papillomavirus (HPV) and HPV 16 integration status in cervical intraepithelial neoplasia and carcinoma. Mod Pathol. 2007; 20 (2): 256–66. DOI: 10.1038/modpathol.3800737. Epub 2006 Dec 22. PMID: 17192787.
  12. Yoshida T, Sano T, Oyama T, Kanuma T, Fukuda T. Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma. Virchows Arch. 2009; 455 (3): 253– 9. DOI: 10.1007/s00428-009-0823-x. PMID: 19727809.
  13. Halec G, Schmitt M, Dondog B, Sharkhuu E, Wentzensen N, Gheit T, Tommasino M, Kommoss F, Bosch FX, Franceschi S, Clifford G, Gissmann L, Pawlita M. Biological activity of probable/possible high-risk human papillomavirus types in cervical cancer. Int J Cancer. 2013; 132 (1): 63–71. DOI: 10.1002/ijc.27605. Epub 2012 Jul 9. PMID: 22514107.
  14. Andreev AO. Taktika vedenija pacientok s ploskokletochnymi porazhenijami shejki matki s uchetom opredelenija genotipa i virusnoj nagruzki VPCh [dissertacija]. M., 2024. Russian.
  15. Halec G, Schmitt M, Dondog B, Sharkhuu E, Wentzensen N, Gheit T, Tommasino M, Kommoss F, Bosch FX, Franceschi S, Clifford G, Gissmann L, Pawlita M. Biological activity of probable/possible high-risk human papillomavirus types in cervical cancer. Int J Cancer. 2013; 132 (1): 63–71. DOI: 10.1002/ijc.27605. Epub 2012 Jul 9. PMID: 22514107.