Funding: the study was conducted within the framework of the State Assignment No. 124040300006-2 “Development of a test system to detect early signs of cervical and endometrial cancer based on epigenetic DNA analysis in cervical smears”.

Acknowledgements: the authors would like to thank A.R. Zaretsky, head of the Laboratory of Molecular Oncogenetics, Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, for valuable comments on the study concept and analysis of the results.

Author contribution: Bayramova GR, Trofimov DYu — study concept and design; Andreev AO, Bourmenskaya OV — data acquisition and processing; Asaturova AV, Bourmenskaya OV — statistical data processing; Andreev AO, Piven VD — manuscript writing; Bayramova GR, Asaturova AV — manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (protocol No. 11 dated 25 November 2021) and conducted in full compliance with the requirements for confidentiality of personal dara, ethical standards and principles of conducting medical studies involving humans stated in the Declaration of Helsinki of the World Medical Association “Ethical principles for medical research involving human subjects”.