ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Genetic polymorphism of the NF-kB1 р105/р50 processing region in pulmonary tuberculosis
About authors
Kemerovo State Medical University, Kemerovo, Russia
Correspondence should be addressed: Alina V. Meyer
Voroshilov, 22а, Kemerovo, 650056, Russia; ur.xednay@anila-opahs
About paper
Funding: the study was conducted within the framework of the basic budgetary funding source for project of the State Assignment of the Ministry of Health of the Russian Federation (agreement No. 056-03-2023-050 dated 17.01.2023).
Author contribution: Meyer AV, Lavryashina MB — developing the study concept and design, manuscript writing and final approval; Thorenko BA — genotyping, statistical analysis, working with the database; Imekina DO — genotyping, statistical analysis, technical editing; Dutchenko AP — search for literature, manuscript writing; Pyanzova TV — research management, clinical and biological material collection, final approval of the manuscript; Karabchukov KB — clinical history taking.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Kemerovo State Medical University (protocol No. 301 dated 08 February 2023) and conducted in accordance with the ethical principles stated in the WMA Declaraction of Helsinki; the written informed consent to participation in the study was obtained from all patients.
Received: 2024-12-23
Accepted: 2025-02-06
Published online: 2025-02-19
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Table 1. Characteristics of the studied NFKB1 SNP complex (according to Ensembl, http://www.ensembl.org)
Note: I — intron, E — exon, * — alternative variants analyzed in the study.
Table 2. Frequencies of the rs4648050, rs4648051, rs4648055, rs4648058, rs4648068, rs1609993 alternative alleles in the gene NFKB1 in the studied sample, global and European populations
Note: χ2X-W — criterion for estimation of the Hardy–Weinberg equilibrium; χ2 — criterion for pairwise comparison of frequencies; Alt — alternative allele frequency; MAF — minor allele frequency in the global population (Global) and European population (EUR), the χ2 indices represent variants of pairwise comparison: TB — of population control with the group of TB patients; GLOBAL — of both studied samples with frequencies in the global population; EUR — with frequencies in the European population. Statistically significant values are highlighted in bold.
Table 3. Distribution of the rs4648050, rs4648051, rs4648055, rs4648058, rs4648068, rs1609993 genotypes in the gene NFKB1 and indicators of association with TB
