2025 / 01

Next Paper
DOI: 10.24075/brsmu.2025.004
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Genetic polymorphism of the NF-kB1 р105/р50 processing region in pulmonary tuberculosis

Meyer AV, Thorenko BA, Imekina DO, Dutchenko AP, Pyanzova TV, Karabchukov KB, Lavryashina MB
About authors

Kemerovo State Medical University, Kemerovo, Russia

Correspondence should be addressed: Alina V. Meyer
Voroshilov, 22а, Kemerovo, 650056, Russia; ur.xednay@anila-opahs

About paper

Funding: the study was conducted within the framework of the basic budgetary funding source for project of the State Assignment of the Ministry of Health of the Russian Federation (agreement No. 056-03-2023-050 dated 17.01.2023).

Author contribution: Meyer AV, Lavryashina MB — developing the study concept and design, manuscript writing and final approval; Thorenko BA — genotyping, statistical analysis, working with the database; Imekina DO — genotyping, statistical analysis, technical editing; Dutchenko AP — search for literature, manuscript writing; Pyanzova TV — research management, clinical and biological material collection, final approval of the manuscript; Karabchukov KB — clinical history taking.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Kemerovo State Medical University (protocol No. 301 dated 08 February 2023) and conducted in accordance with the ethical principles stated in the WMA Declaraction of Helsinki; the written informed consent to participation in the study was obtained from all patients.

Received: 2024-12-23 Accepted: 2025-02-06 Published online: 2025-02-19
|
  1. Global Tuberculosis Report 2023. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023 (30.11.2024).
  2. Khan PY, Yates TA, Osman M, Warren RM, van der Heijden Y, Padayatchi N, et al. Transmission of drug-resistant tuberculosis in HIV-endemic settings. Lancet Infect Dis. 2019; 19 (3): e77–e88. DOI: 10.1016/S1473-3099(18)30537-1.
  3. Liebenberg D, Gordhan BG, Kana BD. Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management. Front Cell Infect Microbiol. 2022; 12: 943545. DOI: 10.3389/fcimb.2022.943545.
  4. Dohal M, Porvaznik I, Solovič I, Mokry J. Advancing tuberculosis management: the role of predictive, preventive, and personalized medicine. Front Microbiol. 2023; 14: 1225438. DOI: 10.3389/fmicb.2023.1225438.
  5. Shabani S, Farnia P, Ghanavi J, Velayati AA, Farnia P. Pharmacogenetic Study of Drugs Affecting Mycobacterium tuberculosis. Int J Mycobacteriol. 2024; 13 (2): 206–12. DOI: 10.4103/ijmy.ijmy_106_24.
  6. Aravindan PP. Host genetics and tuberculosis: Theory of genetic polymorphism and tuberculosis. Lung India. 2019; 36 (3): 244– 52. DOI: 10.4103/lungindia.lungindia_146_15.
  7. Abhimanyu Bose M, Giri A, Varma-Basil M. Comparative Genetic Association Analysis of Human Genetic Susceptibility to Pulmonary and Lymph Node Tuberculosis. Genes (Basel). 2023; 14 (1): 207. DOI: 10.3390/genes14010207.
  8. Murugesan H, Sampath P, A VK, R S, Veerasamy A, Ranganathan U, et all. Association of CYP27B1 gene polymorphisms with pulmonary tuberculosis and vitamin D levels. Gene. 2024; 927: 148679. DOI: 10.1016/j.gene.2024.148679.
  9. Samimi R, Hosseinpanahi A, Zaboli R, Peymani A, Rouhi S, Ahmadi Gooraji S, et all. Prevalence of Vitamin D Receptor Genes Polymorphisms in People with Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis. Med J Islam Repub Iran. 2024; 38: 32. DOI: 10.47176/mjiri.38.32.
  10. Ferluga J, Yasmin H, Al-Ahdal MN, Bhakta S, Kishore U. Natural and trained innate immunity against Mycobacterium tuberculosis. Immunobiology. 2020; 225 (3): 151951. DOI: 10.1016/j.imbio.2020.151951.
  11. Wang Y, Shi Q, Chen Q, Zhou X, Yuan H, Jia X, et all. Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host. Front Cell Infect Microbiol. 2022; 12: 956311. DOI: 10.3389/fcimb.2022.956311.
  12. Stutz MD, Clark MP, Doerflinger M, Pellegrini M. Mycobacterium tuberculosis: Rewiring host cell signaling to promote infection. J Leukoc Biol. 2018; 103 (2): 259–68. DOI: 10.1002/JLB.4MR0717-277R.
  13. Gallant J, Heunis T, Beltran C, Schildermans K, Bruijns S, Mertens I, et all. PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages. Front Immunol. 2021; 12: 702359. DOI: 10.3389/fimmu.2021.702359.
  14. Bullen CK, Singh AK, Krug S, Lun S, Thakur P, Srikrishna G, et all. MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival. JCI Insight. 2023; 8 (20): e166242. DOI: 10.1172/jci.insight.166242.
  15. Mitchell S, Vargas J, Hoffmann A. Signaling via the NFκB system. Wiley Interdiscip Rev Syst Biol Med. 2016; 8 (3): 227–41. DOI: 10.1002/wsbm.1331.
  16. Moorthy AK, Savinova OV, Ho JQ, Wang VYa-F, Vu D, Ghosh G. The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner. EMBO J. 2006; 25 (9): 1945–56. DOI: 10.1038/sj.emboj.7601081.
  17. Liu CW, Wu LS, Lin CJ, Wu HC, Liu KC, Lee SW. Association of tuberculosis risk with genetic polymorphisms of the immune checkpoint genes PDCD1, CTLA-4, and TIM3. PLoS One. 2024; 19 (5): e0303431. DOI: 10.1371/journal.pone.0303431.
  18. Guo XL, Liu XC, Su GB, Zhou CY, Cui QT. Association of NFκB1 gene polymorphisms with coronary artery disease in a Han Chinese population. Genet Mol Res. 2016; 15 (3). DOI: 10,4238/gmr,15038072.
  19. Sarwar S, Tareen MU, Sabir M, Sultan A, Malik SA. NF-κB1 Intronic Region Polymorphisms as Risk Factor for Head and Neck Cancer in HPV-Infected Population from Pakistan. Curr Mol Med. 2022; 22 (1): 74–82. DOI: 10.2174/1566524021666210302144344.
  20. Hua T, Qinsheng W, Xuxia W, Shuguang Z, Ming Q, Zhenxiong L, et all. Nuclear factor-kappa B1 is associated with gastric cancer in a Chinese population. Medicine (Baltimore). 2014; 93 (28): e279. DOI: 10.1097/MD.0000000000000279.
  21. Chen LP, Cai PS, Liang HB. Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer. Genet Mol Res. 2015; 14 (3): 8273–82. DOI: 10.4238/2015.July.27.15.