Funding: the study was supported by the RSF grant No. № 23-15-00135.

Author contribution: Buzenkova AV — literature review, data analysis, acquisition and statistical processing of the results, manuscript writing; Grigoryeva ES — flow cytometry, data analysis, interpretation of the results, manuscript writing; Alifanov VV — flow cytometry, manuscript editing; Tashireva LA, Savelieva OE — discussion, manuscript editing; Pudova ES — flow cytometry; Zavyalova MV — manuscript editing; Cherdyntseva NV — study planning and design, discussion; Perelmuter VM — study planning and management, interpretation of the results, manuscript writing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences (protocol No. 8 dated 17 June 2016) and conducted in accordance with Federal Laws of the Russian Federation (No. 152, 323, etc.), the Declaration of Helsinki (1964) and all later amendments and additions that regulate scientific research involving human biomaterial. All subjects submitted the informed consent to participation in the study.