2025 / 04

DOI: 10.24075/brsmu.2025.041
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Determination of aging phenotype based on the changes in spontaneous and induced interleukin-6 and interleukin-10 production in vitro

Grechenko VV, Gromova TV, Ogurtsova AD, Muradyan TG, Zhuravleva ER, Gankovskaya LV
About authors

Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Tatiana V. Gromova
Ostrovityanova, 1, stroenie 9, Moscow, 117997; moc.liamg@avohsavelvt

About paper

Funding: the study was supported by the Russian Science Foundation grant No. 23-15-00137, https://rscf.ru/project/23-15-00137.

Acknowledgements: to O.N. Tkacheva, Head of the Russian Gerontological Research and Clinical Center, Pirogov Russian National Research Medical University, for the provided biomaterial samples of the group of centenarians; executives of the Diagnostic Clinical Center No. 1, Obruchevsky Social House, branch of the Troparyovo Geriatric Center, for the provided biomaterial samples of patients of older age groups.

Author contribution: Gankovskaya LV — research management and study planning; Grechenko VV, Gromova TV, Ogurtsova AD, Zhuravleva ER — data acquisition, processing, and analysis; Grechenko VV — statistical processing, Muradyan TG — selection of clinical groups; Grechenko VV, Gromova TV, Gankovskaya LV — manuscript writing; Ogurtsova AD — editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Pirogov Russian National Research Medical University (protocol No. 214 dated 13 December 2021). The subjects submitted the informed consent to participation in the study and the consent to data processing.

Received: 2025-08-03 Accepted: 2025-08-20 Published online: 2025-08-30
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