ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Determining targets for personalized multitarget noninvasive stimulation of the frontoparietal control network
About authors
Russian Сenter of Neurology and Neurosciences, Moscow, Russia
Correspondence should be addressed: Alexandra G. Poydasheva
Volokolamskoye shosse, 80, Moscow, 125310, Russia; ur.ygoloruen@avehsadyop
About paper
Funding: the study was conducted as part of the project “Developing a Transcranial Magnetic Stimulation Method to Improve Cognitive Functions in Healthy Individuals” implemented within the framework of the National Project “New Health Preservation Technologies” (registration number 1025020400006-8-3.2.25).
Author contribution: Poydasheva AG, Sinitsyn DO, Bakulin IS — study planning and design; Poydasheva AG, Zabirova AH — literature review; Bakulin IS, Zabirova AH, Lagoda DYu — data acquisition; Sinitsyn DO, Poydasheva AG — data analysis; Poydasheva AG, Sinitsyn DO — manuscript writing; all authors — data interpretation, manuscript editing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Russian Сenter of Neurology and Neurosciences (protocol No. 5-1/25 dated 19 May 2025). All the volunteers signed the informed consent form.
Received: 2025-11-14
Accepted: 2025-12-10
Published online: 2025-12-20
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Fig. 1. Projections of targets in 24 subjects on coordinate planes. Red are targets in the DLPFC, blue are targets in the posterior parietal cortex
Fig. 2. Convex hulls of sets of points with the coordinates of targets in the PPC (Fig. А) and DLPFC (Fig. В)
Fig. 3. Positions of targets for all subjects in the MNI space. Shown in yellow is the group-derived mask of the frontoparietal control network (FPCN) from [20] used as a seed region in the calculations of individual connectivity. Shown in red are the individual targets in DLPFC (defined as the part of the middle frontal gyrus excluding the premotor cortex), shown in blue are the targets in the posterior parietal cortex (defined as the union of the supramarginal and angular gyri and the superior parietal lobule). The data is shown on the mni152 template from the MRIcroGL software
Fig. 4. Comparison of the mean target locations in the DLPFC in MNI space from this study (red) and the paper [24] (green). In the study [24], the point was calculated as the mean of targets defined as peaks of independent components of the individual resting-state fMRI signal visually identified as the FPCN.
Table. Individual coordinates of targets in the left dorsolateral prefrontal cortex and posterior parietal cortex
Note: DLPFC — dorsolateral prefrontal cortex, PPC — posterior parietal cortex, М1 — primary motor cortex.
